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Journal of Lipid Research, Vol. 9, 310-318, May 1968
Copyright © 1968 by Lipid Research, Inc.

Phospholipid spherules (liposomes) as a model for biological membranes

Grazia Sessa and Gerald Weissmann

Department of Medicine, New York University School of Medicine, New York 10016

This review describes the properties of artificial spherules composed of phospholipids and various long-chain anions or cations. The lipids, which are in the liquid-crystal state, trap aqueous solutes such as cations, anions, glucose, or glycine in aqueous compartments between a series of lipid bilayers. The diffusion of these solutes from the spherules can be studied in the same way that diffusion across biological membranes is studied.

The spherules exhibit many of the properties of natural membrane-bounded structures: they are capable of ion-discrimination, osmotic swelling, and response to a variety of physiologic and pharmacologic agents. These agents (steroids, drugs, toxins, antibiotics) accelerate or retard diffusion of ions or molecules from the spherules in a way that qualitatively mimics their action on erythrocytes, lysosomes, or mitochondria.

Thus the spherules constitute a valuable model system with which to study the properties of biological membranes that may be dependent on their lipid components.

Supplementary key words smectic mesophase • liposomes • lipid spherules • model membranes • phospholipids • cholesterol • steroids • drugs • narcotics • toxins • antibiotics

Submitted on November 16, 1967

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