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Journal of Lipid Research, Vol. 9, 353-356, May 1968
Copyright © 1968 by Lipid Research, Inc.

Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone

M. R. Lakshmanan , W. E. J. Phillips , and R. L. Brien

Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, Canada

The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-1-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidogenesis. Liver ubiquinone synthesis was inhibited in CPIB-fed rats, but a block in the catabolism of the ubiquinone resulted in accumulation of ubiquinone in CPIB-fed animals.

Supplementary key words CPIB • cholesterol • ubiquinone • hydrocarbon • biosynthesis • turnover • rat • liver • acetate • mevalonate

Submitted on October 27, 1967
Accepted on February 5, 1968


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