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Journal of Lipid Research, Vol. 9, 509-512, July 1968
Copyright © 1968 by Lipid Research, Inc.

Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man

John R. Crouse , Charles D. Gerson , Leonore M. Decarli , and Charles S. Lieber

Liver Disease and Nutrition Unit, Second (Cornell) Medical Division, Bellevue Hospital, New York 10016 and the Department of Medicine, Cornell University Medical College, New York 10021

To investigate the mechanism by which ethanol lowers plasma free fatty acids, we tested the ability of two products of alcohol metabolism, acetate and lactate, to lower free fatty acids in man. Sodium acetate was given orally to five healthy fasting volunteers and caused a significant fall in plasma free fatty acids. After amounts of ethanol and acetate that produced similar reductions in free fatty acids, plasma acetate increased 3- to 4-fold within 20 min. In each of three subjects the fall of free fatty acids observed after acetate ingestion occurred at plasma acetate levels less than or equal to those reached after ethanol. In all studies plasma glucose remained stable. Oral administration of sodium lactate to another volunteer in amounts sufficient to raise plasma lactate concentrations to a level similar to that found after ethanol administration failed to lower plasma free fatty acids.

Thus acetate, a metabolite of ethanol, reduces plasma free fatty acids at plasma acetate levels comparable to those resulting from ethanol metabolism, which suggests that the lowering of plasma free fatty acids produced by ethanol is mediated, at least in part, by acetate.

Supplementary key words ethanol • free fatty acids • acetate • gas chromatography • lactate

Submitted on January 12, 1968
Accepted on April 8, 1968


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