Journal of Lipid Research, Vol. 9, 602-605, September 1968
Copyright © 1968 by Lipid Research, Inc.

Effects of infusion of some prostaglandins in essential fatty acid-deficient and normal rats

Floyd P. Kupiecki , N. Chandra Sekhar , and James R. Weeks

Departments of Metabolic Research and Pharmacology, The Upjohn Company, Kalamazoo, Michigan 49001

Infusion of 1 mg/kg per day of prostaglandin E₁ (PGE₁) for 2 and 7 wk failed to correct the dermal signs of essential fatty acid (EFA) deficiency in rats despite the known conversion of EFA to certain prostaglandins. PGE₁ caused no significant changes in serum cholesterol, triglycerides, or phospholipids or in liver neutral lipids in EFA-deficient or normal rats. In normal rats epinephrine-induced lipolysis was greater in fat pads from infused than from untreated rats. The effect on epinephrine-induced lipolysis was greater after the 7 wk infusion than after the 2 wk infusion. The 7 wk infusion also lowered plasma free fatty acid (FFA) concentrations. Infusion of PGE₂ and PGF₂ in combination for 4 wk had no significant effect on either dermal signs of EFA deficiency, lipolysis, or plasma FFA concentrations.

Supplementary key words prostaglandin E₁ • E₂ • F₂ • essential fatty acid deficiency • lipolysis • plasma free fatty acids

Submitted on March 28, 1968
Accepted on May 27, 1968

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