Journal of Lipid Research, Vol. 9, 661-666, September 1968
Copyright © 1968 by Lipid Research, Inc.

Effects of a single oral load of medium-chain triglyceride on serum lipid and insulin levels in man

I. Tamir , D. B. Grant , Audrey S. Fosbrooke , M. M. Segall , and June K. Lloyd

Institute of Child Health, University of London, London, England

Analysis of serum free fatty acids by gas-liquid chromatography showed high proportions (27-57%) of octanoic acid for up to 4 hr after the ingestion of a single oral load of medium-chain triglyceride (approximately 1 g/kg body weight) in four volunteers.

The effects of a medium-chain triglyceride load on the concentrations of plasma free long-chain fatty acids, plasma glucose, serum insulin, and serum triglyceride were observed and compared with the effects of a glucose load. A rapid fall in the free long-chain fatty acids followed both loads but only a small rise in serum insulin was observed after medium-chain triglyceride. The fall in free long-chain fatty acids following ingestion of medium-chain triglyceride cannot therefore be caused mainly by the release of insulin and may be due to a direct action on adipose tissue.

No medium-chain fatty acids were detected in the serum triglyceride after ingestion of medium-chain triglyceride, but there was a small but significant increase in the percentage of hexadecenoic acid in this fraction.

Supplementary key words medium-chain triglyceride • octanoic acid • free fatty acids • insulin • glucose • hexadecenoic acid • man

Submitted on December 6, 1967
Accepted on June 26, 1968

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