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Papers In Press, published online ahead of print September 16, 2002
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Submitted on July 31, 2002
Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo 108-8639
Corresponding Author: yoshidak{at}ims.u-tokyo.ac.jp
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase (LPL) activity in vitro.
Revised on September 16, 2002
Accepted on September 4, 2002
Angiopoietin-like protein 4 (ANGPTL4) is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
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