J. Lipid Res.
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A more recent version of this article appeared on July 1, 2007

Papers In Press, published online ahead of print March 30, 2007
J. Lipid Res., doi:10.1194/jlr.C600026-JLR200
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Submitted on December 21, 2006
Revised on March 26, 2007
Accepted on March 29, 2007

Avian Apolipoprotein A-V binds to LDL receptor gene family members

Andrea Dichlberger, Larry A. Cogburn, Johannes Nimpf, and Wolfgang J. Schneider

Department of Medical Biochemistry, Medical University Vienna, Max F. Perutz Laboratories, Vienna A - 1030

Corresponding Author: wolfgang.schneider{at}meduniwien.ac.at

Apolipoprotein (apo) A-V affects plasma triglyceride (TG) levels; however, the properties of apoA-V that mediate its action(s) are still incompletely understood. It is unclear how apoA-V, whose plasma concentration is extremely low, can effect the pronounced TG differences observed in individuals with various apoA-V dysfunctions. To gain novel insights into apoA-V biology, we have now expanded our previous studies in the chicken to this apo. First, we have characterized the first avian apoA-V, reveal its expression not only in liver and small intestine, but also in brain, kidney, and ovarian follicles, and show its presence in the circulation. Second, we demonstrate directly that galline apoA-V binds to the major LDL receptor family member (LR) of the laying hen, and that this interaction does not depend on the association of the apo with lipid or lipoproteins. We propose that a direct interaction with LRs may represent a novel, additional mechanism for modulation of TG levels by apoA-V.


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