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A more recent version of this article appeared on February 1, 2003

Papers In Press, published online ahead of print October 1, 2002
J. Lipid Res., doi:10.1194/jlr.M200006-JLR200
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Submitted on January 4, 2002
Revised on July 25, 2002
Accepted on September 20, 2002

Biological and genetic determinants of serum apolipoprotein CIII concentration. Reference limits from the stanislas cohort

Peggy Tilly, Catherine Sass, Monique Vincent-Viry, Dominique Aguillon, Gerard Siest, and Sophie Visvikis

Centre de Médecine Préventive, INSERM U525, Vandoeuvre 54500

Corresponding Author: Gerard.Siest{at}cmp.u-nancy.fr

Apolipoprotein (apo) CIII is involved in triglycerides metabolism, and is therefore important for the pathogenesis of coronary heart diseases. However, to our knowledge, serum apoCIII variation factors and reference limits have never been determined, so the aim of this study was to establish them to facilitate clinical usefulness. We measured serum apoCIII concentration of apparently healthy subjects of the STANISLAS Cohort by an immunoturbidimetric method. Genetic polymorphisms within the APOC3, APOE, APOAIV and LPL genes were determined by a multiplex PCR. Serum apoCIII concentration varied from 28.2 mg/L to 225.8 mg/L in the overall sample and between subjects variability was about 30%. Factors influencing apoCIII concentration were age, BMI in adult men, alcohol consumption in adults, oral contraceptive intake in women, the post-pubescent status in boys. The APOC3 1100T allele in adult men and the APOC3 -455C allele in boys were associated with increased apoCIII concentration. The APOA4 360His allele was associated with decreased apoCIII concentration in women. We also established reference limits of serum apoCIII concentration according to age and gender.


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