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A more recent version of this article appeared on January 1, 2003

Papers In Press, published online ahead of print October 16, 2002
J. Lipid Res., doi:10.1194/jlr.M200136-JLR200
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Submitted on March 26, 2002
Revised on August 8, 2002
Accepted on October 2, 2002

Bio-mimetic lipid/polymer colorimetric membranes: Molecular and cooperative properties

Sofiya Kolusheva, Ellen Wachtel, and Raz Jelinek

Chemistry Dept., Ben Gurion University, Beersheva 84105

Corresponding Author: razj{at}bgumail.bgu.ac.il

Characterization of membranes and of biological processes occurring within membranes is essential for understanding fundamental cellular behavior. Here we present a detailed biophysical study of a recently developed colorimetric bio-mimetic membrane assembly constructed from physiological lipid molecules and conjugated polydiacetylene. Various analytical techniques have been applied to characterize the organization of the lipid components in the chromatic vesicles and their contributions to the observed blue-to-red color transitions. Experiments reveal that both the polymerized units as well as the lipids exhibit microscopic phases and form domains whose properties and bilayer organization are interdependent. These domains are interspersed within mixed lipid/polymer vesicles which have a size distribution different from those of aggregates of the individual molecular constituents. The finding that fluidity changes induced within the lipid domains are correlated with the chromatic transitions demonstrates that the colorimetric platform can be used to evaluate the effects of individual molecular components, such as negatively charged lipids and cholesterol, upon membrane fluidity and thermal stability.


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[Abstract] [Full Text] [PDF]


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