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Papers In Press, published online ahead of print September 1, 2002
J. Lipid Res., doi:10.1194/jlr.M200218-JLR200
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Submitted on June 4, 2002
Div. Metabolic Disorders & Nutritional Medicine, Dr von Hauner Children's Hospital, Univ of Munich, Muenchen, Bavaria D-80337
Corresponding Author: bkoletz{at}kk-i.med.uni-muenchen.de
Most preterm infant formulas contain medium-chain triacylglycerols (MCT), but the effects of MCT on polyunsaturated fatty acid status and metabolism are still controversial.. Thus Using stable isotope methodology we studied the effects of MCT in infant formulas on the metabolism of linoleic acid metabolism in preterm infants using stable isotopes. Enterally fed preterm infants (n=19) were randomised ly assigned to receive for 7 days a preterm infant formula with 40% of fat as MCT (MCT group, n=10) or a formula without MCT (control group, n=9), with otherwise similar composition and similar linoleic and a-linolenic acid content. At study day 5, infants received orally 2 mg/kg body weight of uniformly 13C labeledlabelled linoleic acid. Fatty acids in plasma lipid classes and 13C enrichment of phospholipid fatty acids were measured 24h and 48h thereafter, and tracer oxidation was monitored by breath gas analysis. In comparison Compared to the control group, the MCT group showed lower recovery of 13C in breath 13CO2 (3.0% vsvs. 5.6% of the applied dose, p<0.01) and higher plasma triacylglycerol contents of octanoic acid, of decanoic acid and of total long-chain polyunsaturated fatty acids (57.1±4.4 µmol/L vs. 37.9±4.8 µmol/L, p<0.01, p < 0.05). Furthermore,Concentrations of several polyunsaturated fatty acids concentrations in plasma phospholipids and free non esterified fatty acids were higher in the MCT group. 13C concentrations in phospholipid n-6 fatty acids indicated no difference in the relative conversion of linoleic to arachidonic acid. We conclude that oral MCT effectively reduce linoleic acid oxidation and enhance total polyunsaturated fatty acid and n-6 long chain polyunsaturated fatty acid tissue availabilityoxidation in preterm infants, without compromising endogenous n-6 long chain polyunsaturated fatty acid synthesis, because the relative conversion of linoleic acid into its longer chain metabolites is not altered.
Revised on August 19, 2002
Accepted on August 20, 2002
Plasma lipid fatty acid composition and metabolism of 13C-labeled linoleic acid in preterm infants fed a formula containing medium-chain triacylglycerols
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