Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


A more recent version of this article appeared on January 1, 2003

Papers In Press, published online ahead of print September 1, 2002
J. Lipid Res., doi:10.1194/jlr.M200218-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M200218-JLR200v1
44/1/41    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rodriguez, M.
Right arrow Articles by Koletzko, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rodriguez, M.
Right arrow Articles by Koletzko, B.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on June 4, 2002
Revised on August 19, 2002
Accepted on August 20, 2002

Plasma lipid fatty acid composition and metabolism of 13C-labeled linoleic acid in preterm infants fed a formula containing medium-chain triacylglycerols

Maria Rodriguez, Simone Kiss, Maria Fink, Hans Demmelmair, Marco Turini, Gayle Crozier, and Berthold Koletzko

Div. Metabolic Disorders & Nutritional Medicine, Dr von Hauner Children's Hospital, Univ of Munich, Muenchen, Bavaria D-80337

Corresponding Author: bkoletz{at}kk-i.med.uni-muenchen.de

Most preterm infant formulas contain medium-chain triacylglycerols (MCT), but the effects of MCT on polyunsaturated fatty acid status and metabolism are still controversial.. Thus Using stable isotope methodology we studied the effects of MCT in infant formulas on the metabolism of linoleic acid metabolism in preterm infants using stable isotopes. Enterally fed preterm infants (n=19) were randomised ly assigned to receive for 7 days a preterm infant formula with 40% of fat as MCT (MCT group, n=10) or a formula without MCT (control group, n=9), with otherwise similar composition and similar linoleic and a-linolenic acid content. At study day 5, infants received orally 2 mg/kg body weight of uniformly 13C labeledlabelled linoleic acid. Fatty acids in plasma lipid classes and 13C enrichment of phospholipid fatty acids were measured 24h and 48h thereafter, and tracer oxidation was monitored by breath gas analysis. In comparison Compared to the control group, the MCT group showed lower recovery of 13C in breath 13CO2 (3.0% vsvs. 5.6% of the applied dose, p<0.01) and higher plasma triacylglycerol contents of octanoic acid, of decanoic acid and of total long-chain polyunsaturated fatty acids (57.1±4.4 µmol/L vs. 37.9±4.8 µmol/L, p<0.01, p < 0.05). Furthermore,Concentrations of several polyunsaturated fatty acids concentrations in plasma phospholipids and free non esterified fatty acids were higher in the MCT group. 13C concentrations in phospholipid n-6 fatty acids indicated no difference in the relative conversion of linoleic to arachidonic acid. We conclude that oral MCT effectively reduce linoleic acid oxidation and enhance total polyunsaturated fatty acid and n-6 long chain polyunsaturated fatty acid tissue availabilityoxidation in preterm infants, without compromising endogenous n-6 long chain polyunsaturated fatty acid synthesis, because the relative conversion of linoleic acid into its longer chain metabolites is not altered.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
J. Nutr.Home page
J. Mane, E. Pedrosa, V. Loren, I. Ojanguren, L. Fluvia, E. Cabre, G. Rogler, and M. A. Gassull
Partial Replacement of Dietary (n-6) Fatty Acids with Medium-Chain Triglycerides Decreases the Incidence of Spontaneous Colitis in Interleukin-10-Deficient Mice
J. Nutr., March 1, 2009; 139(3): 603 - 610.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
H.-W. Hsu, T. H. Zytkovicz, A. M. Comeau, A. W. Strauss, D. Marsden, V. E. Shih, G. F. Grady, and R. B. Eaton
Spectrum of Medium-Chain Acyl-CoA Dehydrogenase Deficiency Detected by Newborn Screening
Pediatrics, May 1, 2008; 121(5): e1108 - e1114.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
F. Lehner, H. Demmelmair, W. Roschinger, T. Decsi, M. Szasz, K. Adamovich, R. Arnecke, and B. Koletzko
Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants
J. Lipid Res., February 1, 2006; 47(2): 404 - 411.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement