J. Lipid Res.
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A more recent version of this article appeared on December 1, 2002

Papers In Press, published online ahead of print September 1, 2002
J. Lipid Res., doi:10.1194/jlr.M200242-JLR200
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Submitted on June 21, 2002
Revised on August 19, 2002
Accepted on August 22, 2002

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, and Akira Tokumura

Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-0195

Corresponding Author: sugiurat{at}pharm.teikyo-u.ac.jp

Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues and cells. In the present study, we first examined whether lysophosphatidic acid is present in human saliva. We found that a significant amount of lysophosphatidic acid is present in the saliva (0.785 nmol/ml). The predominant fatty acyl moiety of lysophosphatidic acid was 18:1n-9 + n-7 followed by 18:0 and 16:0. A small amount of lysoplasmanic acid, an alkyl ether-linked analog of lysophosphatidic acid, was also detected in the saliva (0.104 nmol/ml). We found that physiologically relevant concentrations of lysophosphatidic acid induced accelerated growth of cells of mouth, pharynx and esophagus origin in vitro. Lysophosphatidic acid also induced rapid increases in the intracellular free Ca2+ concentrations in these cells. We obtained evidence that lysophosphatidic acid receptor mRNAs are actually present in these cells. These results strongly suggest that lysophosphatidic acid is involved in wound healing in the upper digestive organs such as the mouth, pharynx and esophagus.


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