J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on December 1, 2002

Papers In Press, published online ahead of print October 1, 2002
J. Lipid Res., doi:10.1194/jlr.M200279-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M200279-JLR200v1
43/12/2077    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rigot, V.
Right arrow Articles by Chimini, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rigot, V.
Right arrow Articles by Chimini, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on July 18, 2002
Revised on September 16, 2002
Accepted on September 17, 2002

Distinct sites on ABCA1 control distinct steps required for cellular release of phospholipids

Veronique Rigot, Yannick Hamon, Olivier Chambenoit, Melanie Alibert, Nicolas Duverger, and Giovanna Chimini

Centre d'Immunologie, INSERM CNRS de Marseille Luminy, Marseille 13288

Corresponding Author: chimini{at}ciml.univ-mrs.fr

The loss of ABCA1 function leads to Tangier dyslipidemia in humans and to a Tangier-like phenotype in mice, by impairing the transformation of nascent apoproteins into mature HDL particles. Mechanistically this ensues from the inability of cells to release membrane lipids and cholesterol. Whereas the ability of ABCA1 to promote phospholipid effluxes, surface binding of apoproteins and outward flip of membrane lipids has been documented, the relationships between this series of ABCA1-dependent events lies still elusive. Here we provide evidence that i) lipid effluxes require both flip of membrane lipids and binding of apoproteins to the cell surface ii) apoA-I binding depends on structural determinants on ABCA1 and iii) phospholipid effluxes can be modulated by engineered mutations on the structural determinants identified on ABCA1.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Circ. Res.Home page
J. F. Oram and A. M. Vaughan
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease
Circ. Res., November 10, 2006; 99(10): 1031 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. R. Singaraja, H. Visscher, E. R. James, A. Chroni, J. M. Coutinho, L. R. Brunham, M. H. Kang, V. I. Zannis, G. Chimini, and M. R. Hayden
Specific Mutations in ABCA1 Have Discrete Effects on ABCA1 Function and Lipid Phenotypes Both In Vivo and In Vitro
Circ. Res., August 18, 2006; 99(4): 389 - 397.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Trompier, M. Alibert, S. Davanture, Y. Hamon, M. Pierres, and G. Chimini
Transition from Dimers to Higher Oligomeric Forms Occurs during the ATPase Cycle of the ABCA1 Transporter
J. Biol. Chem., July 21, 2006; 281(29): 20283 - 20290.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. F. Oram and J. W. Heinecke
ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease
Physiol Rev, October 1, 2005; 85(4): 1343 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Alder-Baerens, P. Muller, A. Pohl, T. Korte, Y. Hamon, G. Chimini, T. Pomorski, and A. Herrmann
Headgroup-specific Exposure of Phospholipids in ABCA1-expressing Cells
J. Biol. Chem., July 15, 2005; 280(28): 26321 - 26329.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Roosbeek, F. Peelman, A. Verhee, C. Labeur, H. Caster, M. F. Lensink, C. Cirulli, J. Grooten, C. Cochet, J. Vandekerckhove, et al.
Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter
J. Biol. Chem., September 3, 2004; 279(36): 37779 - 37788.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Munehira, T. Ohnishi, S. Kawamoto, A. Furuya, K. Shitara, M. Imamura, T. Yokota, S. Takeda, T. Amachi, M. Matsuo, et al.
{alpha}1-Syntrophin Modulates Turnover of ABCA1
J. Biol. Chem., April 9, 2004; 279(15): 15091 - 15095.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
M. L. Fitzgerald, A. L. Morris, A. Chroni, A. J. Mendez, V. I. Zannis, and M. W. Freeman
ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux
J. Lipid Res., February 1, 2004; 45(2): 287 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. R. Singaraja, L. R. Brunham, H. Visscher, J. J.P. Kastelein, and M. R. Hayden
Efflux and Atherosclerosis: The Clinical and Biochemical Impact of Variations in the ABCA1 Gene
Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1322 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Wang and A. R. Tall
Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux
Arterioscler. Thromb. Vasc. Biol., July 1, 2003; 23(7): 1178 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. R. Tanaka, S. Abe-Dohmae, T. Ohnishi, R. Aoki, G. Morinaga, K.-i. Okuhira, Y. Ikeda, F. Kano, M. Matsuo, N. Kioka, et al.
Effects of Mutations of ABCA1 in the First Extracellular Domain on Subcellular Trafficking and ATP Binding/Hydrolysis
J. Biol. Chem., February 28, 2003; 278(10): 8815 - 8819.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.