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Papers In Press, published online ahead of print December 1, 2002
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Lipid and Diabetes Research Center, Saint Luke's Hospital, Kasnas City, MO 64111
Corresponding Author: wharris{at}saint-lukes.org
Omega-3 fatty acids (FA) reduce postprandial triacylglycerol (TG) concentrations. This study was undertaken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. Healthy subjects (n=33) began with a 4-week, olive oil placebo (4 g/d) run-in period. After a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (SAF), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) group for 4 weeks. Results for EPA and DHA were similar and therefore the data were combined into one
Revised on November 8, 2002
Accepted on November 22, 2002
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
-3 FA group. Omega-3 FA supplementation reduced the postprandial TG, and apo B48 and B100 concentrations by 16% (p=0.08), 28% (p<0.001) and 24% (p<0.01), respectively. Chylomicron TG half-lives in the fed state were reduced after -3 FA treatment (6.0 +/- 0.5 vs. 5.1 +/- 0.4 min; p<0.05), but not after SAF (6.9 +/- 0.7 vs. 7.1 +/- 0.7 min). Omega-3 FA supplementation decreased chylomicron particle sizes (mean diameter; 293 +/- 44 vs. 175 +/- 25 nm; p<0.01) and increased pre-heparin lipoprotein lipase (LpL; 0.6 +/- 0.1 vs. 0.9 +/- 0.1 
mol/h/mL; p<0.05) activity during the fed state, but had no effect on post-heparin LpL or hepatic lipase activities. The results suggest that -3 FA supplementation accelerates chylomicron TG clearance by increasing LpL activity, and that EPA and DHA are equally effective.
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