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Papers In Press, published online ahead of print March 16, 2003
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Internal Medicine, University of Iowa, Iowa City, IA 52242
Corresponding Author: f-jeffrey-field{at}uiowa.edu
Hamsters were fed for 2 weeks a control diet or diets containing palm, olive, safflower, or fish oil. In villus cell populations from duodenum, jejunum, and ileum, rates of intestinal fatty acid and cholesterol synthesis were estimated as were sterol regulatory element-binding protein (SREBP)-1a, SREBP-1c, SREBP-2, HMG-CoA synthase, fatty acid synthase, ATP citrate lyase, acetyl-CoA carboxylase mRNA levels and SREBP-1 and SREBP-2 mass. Plasma cholesterol and triacylglcerol levels were increased in animals ingesting palm oil and decreased in animals ingesting fish oil. Fatty acid synthesis and fatty acid synthase activity were decreased in proximal intestine of animals ingesting all the fat-containing diets. Intestinal cholesterol synthesis was unaltered. In animals fed fat, SREBP-1c gene expression was modestly increased in duodenum of hamsters fed palm or olive oil and decreased in animals ingesting safflower or fish oil. Fatty acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, SREBP-2 and HMG-CoA synthase mRNA levels were not altered nor were SREBP-1 or SREBP-2 mass. In intestine, dietary polyunsaturated fatty acids suppress SREBP-1c mRNA without altering expression of its target genes, fatty acid synthase, acetyl-CoA carboxylase, or ATP citrate lyase. Fatty acid influx decreases intestinal fatty acid synthesis by a posttranscriptional mechanism independent of the SREBP pathway.
Revised on March 4, 2003
Accepted on March 10, 2003
Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of sterol regulatory element-binding protein-1 expression
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