J. Lipid Res. Acyl Labeled PIP's available August 1, 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on August 1, 2003

Papers In Press, published online ahead of print May 1, 2003
J. Lipid Res., doi:10.1194/jlr.M300061-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M300061-JLR200v1
44/8/1530    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saito, H.
Right arrow Articles by Igarashi, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saito, H.
Right arrow Articles by Igarashi, O.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Submitted on February 4, 2003
Revised on April 30, 2003
Accepted on May 1, 2003

gamma -Tocotrienol, a vitamin E homologue, is a natriuretic hormone precursor

Hisako Saito, Chikako Kiyose, Hiroyuki Yoshimura, Tadahiko Ueda, Kazuo Kondo, and Osamu Igarashi

Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo 112-8610

Corresponding Author: hisakosaito{at}hotmail.com

2,7,8-Trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), a metabolite of gamma-tocopherol and gamma-tocotrienol, was identified as a new endogenous natriuretic factor. However, gamma-tocopherol and gamma-tocotrienol, both precursors of gamma-CEHC, have never directly been observed to have natriuretic potency. Thus, we investigated if gamma-tocotrienol could cause natriuresis and diuresis in rats. The rats were divided to two groups given a control or a high sodium diet for four weeks, then subdivided to a placebo and gamma-tocotrienol subgroup given only corn oil removed vitamin E and the oil supplemented gamma-tocotrienol, respectively. After oral administration of three experimental doses, rat urine was collected and gamma-CEHC, urine volume, sodium and potassium content were determined. Only in rats given a high NaCl diet did gamma-tocotrienol accelerate and increase sodium excretion, showing no effect on potassium excretion. Sodium excretion in the high NaCl group given gamma-tocotrienol showed 5.06 ± 2.70 g/ d, while in the control group given gamma-tocotrienol was 0.11 ± 0.06 g/ d. Furthermore, gamma-tocotrienol affected urine volume in the specific condition of high NaCl body stores and gamma-tocotrienol supplementation. In this study, we found that gamma-tocotrienol, one of the natural vitamin E homologues, stimulates sodium excretion in vivo suggesting that gamma-tocotrienol possesses a hormone-like natriuretic function.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
C. Zhou, M. M. Tabb, A. Sadatrafiei, F. Grun, and B. Blumberg
TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES
Drug Metab. Dispos., October 1, 2004; 32(10): 1075 - 1082.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.