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J. Lipid Res.
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A more recent version of this article appeared on November 1, 2003

Papers In Press, published online ahead of print August 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300124-JLR200
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Submitted on March 24, 2003
Revised on July 31, 2003
Accepted on August 4, 2003

The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males

Juan Antonio Moreno, José López-Miranda, Carmen Marín, Purificación Gómez, Pablo Pérez-Martínez, Francisco Fuentes, Rafael Angel Fernández de la Puebla, Juan Antonio Paniagua, José María Ordovas, and Francisco Pérez-Jiménez

Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Cordoba 14004

Corresponding Author: juanmorenogu{at}yahoo.es

ABSTRACT Background: Apolipoprotein E (APOE) is a structural component of several lipoprotein particles and plays a central role in the metabolism of triacylglycerol-rich lipoproteins (TRL). Recently, a polymorphism in the apoE regulatory region has been reported to be associated with increased risk of myocardial infarction (MI), premature coronary heart disease (CHD) and decreased plasma APOE concentrations. The aim of this study was to determine whether the apoE gene promoter (-219G/T) polymorphism could modify the postprandial response of TRL in young normolipemic males. Design and methods: Fifty-one healthy APOE 3/3 male volunteers (8 with the -219TT genotype, 29 with the -219GT genotype and 14 with the -219GG genotype) were given a vitamin A fat loading test consisting of 1 g of fat/kg body weight and 60,000 IU of vitamin A. Blood samples were taken at time 0 and every hour until the 6th hour and every 2 hours and 30 minutes until the 11th hour. Plasma cholesterol (C), triacylglycerols (TG), APOE, and C, TG, APOB-100, APOB-48, and retinyl palmitate (RP) were determined in lipoprotein fractions. Results: Postprandial lipemia data revealed that subjects with the -219TT genotype had a higher postprandial response of large TRL-cholesterol (p<0.03), large TRL-triacylglycerols (p<0.001), large TRL-retinyl palmitate (RP) (p<0.004), and small TRL-ApoB-48 (p<0.03) than carriers of the -219G allele. Moreover, the -219TT subjects had the lowest levels of serum APOE (p<0.05). Conclusion: Our data suggest that the –219G/T polymorphism located in the apoE gene promoter region may influence TRL metabolism during the postprandial period, thus prolonging postprandial lipemia in subjects with the TT genotype.


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