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Papers In Press, published online ahead of print October 16, 2003
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Medicine, Division of Cardiology, Mike Rosenbloom Laborabory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec H3A 1A1
Corresponding Author: Katherine.Cianflone{at}mcgill.ca
The aim of the present study was to compare plasma triglyceride (TG) and non-esterified fatty acid (NEFA) clearance in normals stratified by plasma ASP and gender to determine the contribution of fasting ASP. A healthy normal population of 70 men and 71 women was tested for postprandial responses to a high fat mixed meal. Subjects were divided into three tertiles, according to fasting ASP. In the highest ASP tertile only, there was a significant decrease in plasma ASP over the 8 hours (909.7 nM to 705.9 nM, p<0.05 males and 61.94.0 nM to 45.66.2 nM, p<0.01 females). Postprandial TG was progressively delayed from lowest to highest ASP tertile, (p<0.0001, 2-way ANOVA, both genders), with the greatest differences in males. In both men and women, fasting ASP correlated positively with postprandial TG response. Postprandial NEFA increased over 8 hours and progressively increased from lowest to highest ASP tertile, with more pronounced changes in males than females. Stepwise-multiple-regression determined that the best prediction of postprandial TG was: [fasting ASP + apolipoprotein B + insulin + TG; r = 0.806] for men and [fasting ASP + total cholesterol; r = 0.574] for women. In neither gender did leptin, BMI or any other fasting variables improve the prediction. Thus in men and women, ASP significantly predicted postprandial TG and NEFA clearance, both of which were significantly more rapid in women compared to men. Fatty acid trapping appeared to be more rapid in women than in men and based on their lower plasma ASP levels, women may be more ASP sensitive than men. Plasma ASP may be useful as a fasting variable that will provide additional information regarding postprandial TG and NEFA clearance.
Revised on September 30, 2003
Accepted on October 8, 2003
Fasting acylation stimulating protein is predictive of postprandial triglyceride clearance
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