J. Lipid Res.
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A more recent version of this article appeared on November 1, 2003

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J. Lipid Res., doi:10.1194/jlr.M300235-JLR200
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Submitted on June 2, 2003
Revised on July 22, 2003
Accepted on July 23, 2003

Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue

Dominique Letexier, Claudie Pinteur, Valérie Large, Vincent Fréring, and Michel Beylot

INSERM U499, 69008, Lyon

Corresponding Author: beylot{at}laennec.univ-lyon1.fr

Lipogenesis is considered less active in human than in rat adipose tissue. This could be explained by different nutritional conditions: high carbohydrate (HCHO) diet in rats, high fat (HF) diet in humans. Adipose tissue was sampled (post-absorptive state) in: rats and humans receiving a HCHO or HF diet, ad libitum fed humans (C), obese subjects (O). We measured 1) mRNA concentrations of FAS, ACC1, SREBP-1c and ChREBP, 2) SREBP-1c protein, 3) FAS activity. FAS, ACC1, ChREBP and SREBP1-c mRNA concentrations were not modified by diet in humans nor in rats. FAS and ACC1 mRNA levels were lower in humans than in rats (p<0.05). FAS activity was unaffected by diet and was lower in humans (p<0.05). SREBP-1c mRNA concentrations were similar in rats and humans but the precursor and mature forms of SREBP-1c protein were less abundant in humans (p<0.05), without difference between the HCHO and HF groups. ChREBP mRNA concentrations were lower in humans than in rats. Conclusion: the lipogenic capacity of adipose tissue is lower in humans than in rats. This is not related to differences in diet and is probably explained by lower abundance of SREBP-1c protein; a decreased expression of ChREBP could also play a role


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