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A more recent version of this article appeared on September 1, 2003

Papers In Press, published online ahead of print July 1, 2003
J. Lipid Res., doi:10.1194/jlr.M300248-JLR200
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Submitted on June 10, 2003
Revised on July 1, 2003
Accepted on June 16, 2003

Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase

Lluis Fajas, Stéphanie Miard, Michael R. Briggs, and Johan Auwerx

IGBMC, Strasbourg 67404

Corresponding Author: fajas{at}montp.inserm.fr

Selective cyclo-oxygenase-2 (COX-2) inhibitors are non-steroidal anti-inflammatory drugs (NSAID) used in the management of inflammatory diseases. We demonstrate here that inhibition of the COX-2 enzyme impairs adipocyte differentiation. The inhibition of adipogenesis occurs in the early clonal expansion phase. In particular, COX-2 inhibition limits cell cycle re-entry required before terminal adipocyte differentiation. This inhibition of adipogenesis is independent of the production of the PPARg ligand PGJ2, but dependent on the production of proliferative prostaglandins, such as PGE2. Modulation of the activity of COX-2 enzyme, via COX-2 selective inhibitors, might open up new perspectives in the control of obesity and related metabolic diseases.


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