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A more recent version of this article appeared on December 1, 2003

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J. Lipid Res., doi:10.1194/jlr.M300251-JLR200
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Submitted on June 11, 2003
Revised on August 21, 2003
Accepted on August 22, 2003

The apolipoprotein A5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore

Chao-Qiang Lai, E-Shyong Tai, Chee Eng Tan, Jeffery Cutter, Suok Kai Chew, Yue-Ping Zhu, Xian Adiconis, and Jose M. Ordovas

Nutrition & Genomics, Tufts University, Boston, MA 02111

Corresponding Author: jose.ordovas{at}tufts.edu

Singapore comprises three ethnic groups: Chinese (76.7%), Malays (14%) and Asian-Indians (7.9%). Overall, Singaporeans experience coronary heart disease rates similar to those found in the United States. However, there is a dramatic inter-ethnic gradient, with Asian-Indians having significantly higher risk than Chinese and Malays. These differences are associated with high-density lipoprotein cholesterol (HDL-C) levels and cannot be solely explained by environmental exposures, and may be driven by genetic factors. The gene encoding for apolipoprotein A-V (APOA5) has been located on chromosome 11 and it is emerging as an important candidate gene for lipoprotein metabolism. We investigated associations between APOA5 polymorphisms and plasma lipids in 3,971 Singaporeans to establish whether they accounted for some of the ethnic differences in plasma lipids. We found significant associations between the minor alleles at each of four common polymorphisms and higher plasma triglycerides (TG) across ethnic groups. Haplotype analyses showed significant associations with TGs, explaining 6.9%; 5.2%; and 2.7% of the TG variance in Malays, Asian-Indians, and Chinese, respectively. Conversely, we observed significant inverse associations between the minor alleles and HDL-C concentrations for Chinese and Malays. These data suggest that APOA5 plays a role on the ethnic differences observed for plasma TG and HDL-C concentrations.


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