J. Lipid Res.
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A more recent version of this article appeared on January 1, 2004

Papers In Press, published online ahead of print October 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300256-JLR200
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Submitted on June 16, 2003
Revised on October 3, 2003
Accepted on October 7, 2003

Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women

Kristina Linder, Peter Arner, Amilcar Flores-Morales, Petra Tollet-Egnell, and Gunnar Norstedt

Dept of Molecular Medicine, Karolinska Hospital, Stockholm 171 76

Corresponding Author: kristina.linder{at}cmm.ki.se

There is growing evidence that the distribution of adipose tissue in the body is of importance for the development of metabolic complications to obesity, such as diabetes, hypertension and hyperlipidemia. The aim of this study was to identify differentially expressed genes in subcutaneous and omental human adipose tissue in obese men, using a subtractive hybridization strategy. From the obtained set of differentially expressed transcripts we also aimed to identify genes that have a sex-specific pattern of expression in omental or subcutaneous adipose tissue. Representational difference analysis (RDA) was performed on cDNA from subcutaneous and omental fat tissue from a man with extreme abdominal obesity. 44 putatively differentially expressed genes were identified. The obtained RDA-products were spotted onto glass slides to screen for differential expression in other obese patients using a microarray hybridization procedure. Five genes were confirmed to be differentially expressed in subcutaneous or omental adipose tissue from male or female obese patients. One gene was detected only in males, and found to be up-regulated in subcutaneous tissue. The findings extend previous knowledge that different fat depots have a differential gene expression and indicates that sex differences exist in adipose gene expression pattern.


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