J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on March 1, 2004

Papers In Press, published online ahead of print December 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300304-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M300304-JLR200v1
45/3/474    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCloy, U. R.
Right arrow Articles by Cunnane, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCloy, U. R.
Right arrow Articles by Cunnane, S. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on July 9, 2003
Revised on December 2, 2003
Accepted on December 4, 2003

A comparison of the metabolism of eighteen carbon 13C-unsaturated fatty acids in healthy women

Ursula R. McCloy, Mary Ann Ryan, Paul B. Pencharz, Robert J. Ross, and Stephen C. Cunnane

Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2

Corresponding Author: ursula.mccloy{at}utoronto.ca

Altered utilisation of different dietary fatty acids may contribute to several chronic diseases including obesity, non-insulin dependent diabetes mellitus and cardiovascular disease. However, few comparative data are available to support this link so the goal of the present study was to compare the metabolism of 13C-oleate, 13C-alpha-linolenate, 13C-elaidate, and 13C-linoleate through oxidation and incorporation into plasma lipid fractions and adipose tissue. Each tracer was given as a single oral bolus to six healthy women. Samples were collected over 8 days and 13C was analysed using isotope ratio mass spectrometry. At 9 h post-dose, cumulative oxidation was similar for 13C-elaidate, 13C-oleate and 13C-alpha-linolenate (19 +/- 1, 20 +/- 4, 19 +/- 3 % dose, respectively). Significantly lower oxidation of 13C-linoleate (12 +/- 4 % dose; p<0.05) was accompanied by its higher incorporation into plasma phospholipids and cholesteryl esters. Abdominal adipose tissue was enriched with 13C-alpha-linolenate, 13C-elaidate or 13C-linoleate within 6 h. Percent linoleate in plasma phospholipids positively correlated with 13C-linoleate and 13C-elaidate oxidation, indicating a potential role of background diet. Conversion of 13C-linoleate and 13C-alpha-linolenate to longer chain polyunsaturates was a quantitatively minor route of utilisatio


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
K. D. Stark, S.-Y. Lim, and N. Salem Jr.
Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition
J. Lipid Res., November 1, 2007; 48(11): 2471 - 2477.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.