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A more recent version of this article appeared on September 1, 2004

Papers In Press, published online ahead of print July 1, 2004
J. Lipid Res., doi:10.1194/jlr.M300322-JLR200
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Submitted on July 22, 2003
Revised on June 11, 2004
Accepted on June 20, 2004

Regulation of the nitric oxide system in human adipose tissue

Stefan Engeli, Jürgen Janke, Kerstin Gorzelniak, Jana Böhnke, Nila Ghose, Carsten Lindschau, Friedrich C. Luft, and Arya M. Sharma

Department of Nephrology and Hypertension, Charite, Berlin, Berlin 13125

Corresponding Author: engeli{at}fvk.charite-buch.de

Nitric oxide is involved in adipose tissue biology by influencing adipogenesis, insulin-stimulated glucose uptake and lipolysis. The enzymes responsible for nitric oxide formation in adipose cells are eNOS and iNOS, whereas bNOS is not expressed in adipocytes. We characterized the expression pattern, and the influence of adipogenesis, obesity and weight loss on genes belonging to the NO system in human subcutaneous adipose cells by combining in vivo and in vitro studies. Expression of most of the genes known to belong to the nitric oxide system (eNOS, iNOS, subunits of the soluble guanylate cyclase, and both genes encoding cGMP-dependent protein kinases) in human adipose tissue and isolated human adipocytes were detected. In vitro adipogenic differentiation increased the expression level of iNOS significantly, whereas eNOS expression levels were not influenced. The genes encoding eNOS, iNOS, and cGMP-dependent protein kinase 1 were expressed at higher levels in obese women. Expression of these genes, however, was not influenced by 5 % weight loss. Insulin and angiotensin II increased NO production by human preadipocytes in vitro. Increased eNOS and iNOS expression in adipocytes and local effects of insulin and angiotensin II may increase adipose tissue production of NO in obesity.


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