|
 |
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print July 1, 2004
J. Lipid Res., doi:10.1194/jlr.M300322-JLR200
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Nephrology and Hypertension, Charite, Berlin, Berlin 13125
Corresponding Author: engeli{at}fvk.charite-buch.de
Nitric oxide is involved in adipose tissue biology by influencing adipogenesis, insulin-stimulated glucose uptake and lipolysis. The enzymes responsible for nitric oxide formation in adipose cells are eNOS and iNOS, whereas bNOS is not expressed in adipocytes. We characterized the expression pattern, and the influence of adipogenesis, obesity and weight loss on genes belonging to the NO system in human subcutaneous adipose cells by combining in vivo and in vitro studies. Expression of most of the genes known to belong to the nitric oxide system (eNOS, iNOS, subunits of the soluble guanylate cyclase, and both genes encoding cGMP-dependent protein kinases) in human adipose tissue and isolated human adipocytes were detected. In vitro adipogenic differentiation increased the expression level of iNOS significantly, whereas eNOS expression levels were not influenced. The genes encoding eNOS, iNOS, and cGMP-dependent protein kinase 1 were expressed at higher levels in obese women. Expression of these genes, however, was not influenced by 5 % weight loss. Insulin and angiotensin II increased NO production by human preadipocytes in vitro. Increased eNOS and iNOS expression in adipocytes and local effects of insulin and angiotensin II may increase adipose tissue production of NO in obesity.
Revised on June 11, 2004
Accepted on June 20, 2004
Regulation of the nitric oxide system in human adipose tissue
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M.-F. Hsu and T.-C. Meng Enhancement of Insulin Responsiveness by Nitric Oxide-mediated Inactivation of Protein-tyrosine Phosphatases J. Biol. Chem., March 12, 2010; 285(11): 7919 - 7928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species Physiol Rev, January 1, 2009; 89(1): 27 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Kaun, M. Chakaborty-Chatterjee, and M. B. Sokolowski Natural variation in plasticity of glucose homeostasis and food intake J. Exp. Biol., October 1, 2008; 211(19): 3160 - 3166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dallaire, K. Bellmann, M. Laplante, S. Gelinas, C. Centeno-Baez, P. Penfornis, M.-L. Peyot, M. G. Latour, J. Lamontagne, M. E. Trujillo, et al. Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator-Activated Receptor-{gamma} Agonism Diabetes, August 1, 2008; 57(8): 1999 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Kaun, C. A. L. Riedl, M. Chakaborty-Chatterjee, A. T. Belay, S. J. Douglas, A. G. Gibbs, and M. B. Sokolowski Natural variation in food acquisition mediated via a Drosophila cGMP-dependent protein kinase J. Exp. Biol., October 15, 2007; 210(20): 3547 - 3558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Ahmed, N. D.L. Fisher, and N. K. Hollenberg Gender and the Renal Nitric Oxide Synthase System in Healthy Humans Clin. J. Am. Soc. Nephrol., September 1, 2007; 2(5): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Sautin, T. Nakagawa, S. Zharikov, and R. J. Johnson Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress Am J Physiol Cell Physiol, August 1, 2007; 293(2): C584 - C596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Engeli, M. Boschmann, F. Adams, G. Franke, K. Gorzelniak, J. Janke, F. C. Luft, and J. Jordan Dissociation between Adipose Nitric Oxide Synthase Expression and Tissue Metabolism J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2706 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Linscheid, D. Seboek, H. Zulewski, A. Scherberich, N. Blau, U. Keller, and B. Muller Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1068 - E1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Celis, J. M. A. Moreira, T. Cabezon, P. Gromov, E. Friis, F. Rank, and I. Gromova Identification of Extracellular and Intracellular Signaling Components of the Mammary Adipose Tissue and Its Interstitial Fluid in High Risk Breast Cancer Patients: Toward Dissecting The Molecular Circuitry of Epithelial-Adipocyte Stromal Cell Interactions Mol. Cell. Proteomics, April 1, 2005; 4(4): 492 - 522. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |