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Papers In Press, published online ahead of print December 16, 2003
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Lipid Research Center, Laval University, Ste-Foy, Québec G1V 4G2
Corresponding Author: marie-claude.vohl{at}crchul.ulaval.ca
A genome-wide linkage study was performed to identify chromosomal regions harboring genes influencing lipid and lipoprotein levels. Linkage analyses were conducted for four quantitative lipoprotein/lipid traits, i.e. total cholesterol, triglyceride, HDL-C and LDL-C concentrations, in 930 subjects enrolled in the Québec Family Study. A maximum of 534 pairs of siblings from 292 nuclear families was available. Linkage was tested using both an allele sharing and a variance component linkage methods. The strongest evidence of linkage was found on chromosome 12q14.1 at marker D12S334 for HDL-C with a logarithm of the odds (LOD) score of 4.06. Chromosomal regions harboring quantitative trait loci (QTLs) for LDL-C included 1q43 (LOD = 2.50), 11q23.2 (LOD = 3.22), 15q26.1 (LOD = 3.11) and 19q13.32 (LOD = 3.59). In the case of triglycerides, three markers located in 2p14, 11p13 and 11q24.1 provided suggestive evidence of linkage (LOD above 1.75). Tests for total cholesterol levels yielded significant evidence of linkage at 15q26.1 and 18q22.3 with the allele sharing linkage method, but the results were non-significant with the variance component method. In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage.
Revised on December 1, 2003
Accepted on December 7, 2003
Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec family study
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