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A more recent version of this article appeared on September 1, 2004

Papers In Press, published online ahead of print July 1, 2004
J. Lipid Res., doi:10.1194/jlr.M400109-JLR200
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Submitted on March 18, 2004
Revised on May 18, 2004
Accepted on June 16, 2004

Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1

Joline W. J. Beulens, Aafje Sierksma, Arie van Tol, Natalie Fournier, Teus van Gent, Jean-Louis Paul, and Henk F. J. Hendriks

Physiological Sciences, TNO Nutrition and Food Research, Zeist 3700 AJ

Corresponding Author: hendriks{at}voeding.tno.nl

Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and Fu5AH cells, and on other parameters in the RCT pathway. Twenty-three healthy men (45-65 years) participated in a randomized, partially diet-controlled, cross-over trial. They consumed four glasses of whisky (40 g alcohol) or water daily during 17 days. After 17 days of whisky consumption serum capacity to induce ABCA1-dependent cholesterol efflux from J774 mouse macrophages was increased by 17.5% (p= 0.027) as compared to water. Plasma capacity to induce cholesterol efflux from Fu5AH cells increased by 4.6% (p=0.002). Pre-beta HDL, ApoA-I and lipoprotein AI:AII also increased by respectively 31.6, 6.2 and 5.7% (p<0.05) after whisky consumption as compared to water consumption. Changes of cAMP-stimulated cholesterol efflux correlated (r=0.65; p<0.05) with changes of ApoA-I, but not with changes of pre-beta HDL (r=0.30; p=0.18). Cholesterol efflux capacities from serum of lean men were higher than from overweight men. In conclusion, this study shows that moderate alcohol consumption increases the capacity of serum to induce cholesterol efflux from J774 mouse macrophages, which may be mediated by ABCA1.


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