J. Lipid Res.
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A more recent version of this article appeared on February 1, 2005

Papers In Press, published online ahead of print November 16, 2004
J. Lipid Res., doi:10.1194/jlr.M400166-JLR200
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Submitted on April 29, 2004
Revised on November 4, 2004
Accepted on November 8, 2004

The 1784 G > C polymorphism of sterol regulatory element binding protein-2 gene: prevalence and effect on serum lipid concentrations in hyperlipidemic individuals from China

Xueying Duan, Wenli Zhu, Zhentao Zhang, Yao Zhao, Jingjing Dao, Yong Li, and Ying Xiao

Department of Nutrition and Food Hygiene, School of Public Health, Beijing 100083

Corresponding Author: yingxiao6753{at}vip.sina.com

Sterol Regulatory Element Binding Protein-2 is an important nuclear transcription factor in the regulation of cellular cholesterol metabolism. In order to determine allele frequency of 1784G>C polymorphism at SREBP-2 locus and investigate the relationship between this polymorphism and serum lipid levels in Chinese, we selected 486 individuals (118 men and 368 women) from Xicheng District of Beijing. Four groups by lipid levels were considered: hypercholesterolemic subjects, hypertriglyceridemic subjects, combined hyperlipidemic subjects, normal subjects. For all subjects the serum lipids profiles were measured and the 1784G>C polymorphism was analyzed (PCR- RFLP). There was no significant difference in genotype frequencies or allele frequencies of this polymorphism between hyperlipidemic and control groups. The serum TC and LDL-C levels of the individuals carrying C allele were higher than the non-carriers in both male and female hypercholesterolemic group, but only in females statistical significances were observed. The study indicates that SREBP-2 polymorphism can be related with the elevated concentrations of serum TC and LDL-C in hypercholesterolemic subjects, and further work is necessary to confirm the role of 1784G>C polymorphism of SREBP-2 gene in the development of hyperlipidemia.


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