J. Lipid Res.
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A more recent version of this article appeared on February 1, 2005

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J. Lipid Res., doi:10.1194/jlr.M400252-JLR200
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Submitted on July 2, 2004
Revised on November 17, 2004
Accepted on November 17, 2004

Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study

Mary F. Feitosa, Ingrid B. Borecki, Tuomo Rankinen, Treva Rice, Jean-Pierre Després, Yvon C. Chagnon, Jacques Gagnon, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, Claude Bouchard, Michael A. Province, and D. C. Rao

Division of Biostatistics, Washington University, School of Medicine, St. Louis, MO 63110-1093

Corresponding Author: maryf{at}wubios.wustl.edu

Genome-wide multipoint linkage analyses were performed to identify chromosomal regions harboring genes influencing low density lipoprotein (LDL)-cholesterol, total apolipoprotein B (apoB) and LDL-apoB levels using 654 markers. They were assessed in a sedentary state (baseline) and after a 20-week endurance training program. Strong evidence for two quantitative trait loci (QTLs) for baseline levels was found. There are linkage evidence in Black families on chromosomes 1q41-q44 (at marker D1S2860, 238 cM, with a maximum lod score (LOD) of 3.7, for LDL-apoB) and in White families on chromosome 8q24 (at marker D8S1774, 142 cM, with LODs of 3.6, 3.3 and 2.5 for baseline LDL-cholesterol, LDL-apoB and apoB, respectively). There were no strong signals for the lipoprotein training responses (as computed as the difference in post-training – baseline levels). In conclusion, QTLs for baseline apoB and LDL-cholesterol levels on chromosomes 1q41-q44 (in Blacks) and 8q24 (in Whites) were found. As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed.


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