Submitted on October 6, 2004
Revised on December 3, 2004
Accepted on December 14, 2004
A genome scan for serum triglyceride in obese nuclear families
Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, and R. Arlen Price
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
Corresponding Author: arlen{at}bgl.psycha.upenn.edu
Serum triglyceride levels are elevated in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum triglyceride in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (Set 11) were genotyped. Quantitative linkage analyses were performed using family regression and variance components methods. We found linkage on the 7q36 region ( D7S3058, 174 cM, LOD = 2.98) for log transformed triglyceride. We also found suggestive linkages on chromosomes 20 (D20S164, 101 cM, LOD = 2.34), 13 (111 cM, LOD =2.00), 9 (104 cM, LOD = 1.90) as well as some weaker trends for chromosomes 1, 3, 5, 10, 12 and 22. In 58 African American families, LOD scores of 3.66 and 2.62 were observed on two loci on chromosome 16: D16S3369 ( 64 cM ) and MFD466 (100 cM). To verify the 7q36 linkage, we added 60 nuclear families, and the LOD score increased to 3.52 (empirical p < 0.002) on marker D7S3058.
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