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Papers In Press, published online ahead of print January 1, 2005
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Department of Physiology, Université de Bourgogne, Dijon 21000
Corresponding Author: aziz.hichami{at}u-bourgogne.fr
We elucidated the mechanisms of action of two n-3 polyunsaturated fatty acids (PUFAs), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in Jurkat T-cells. Both DHA and EPA were principally incorporated into phospholipids in the following order: PC > PE > PI/PS. Furthermore, two isoforms of phospholipase A2, i.e., calcium-dependent and calcium-independent were implicated in the release of DHA and EPA, respectively, during activation of these cells. The two fatty acids inhibited the PMA-induced plasma membrane translocation of protein kinase C-alpha and -epsilon. The two n-3 PUFAs also inhibited the nuclear translocation of NF-B and the transcription of IL-2 gene in PMA-activated Jurkat T-cells. Together these results demonstrate that DHA and EPA, being released by two isoforms of PLA2, modulate IL-2 gene expression by exerting their action on two PKC isoforms and NF-B in Jurkat T-cells.
Revised on December 21, 2004
Accepted on December 21, 2004
N-3 PUFAs modulate T-cell activation via protein kinase C-
and -
and NF-
B signaling pathway
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