|
 |
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print July 1, 2005
J. Lipid Res., doi:10.1194/jlr.M400489-JLR200
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Medicine and Medical Genetics, University of Washington, Seattle, Seattle, WA 98195-7720
Corresponding Author: pair{at}u.washington.edu
Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than functional PON1 genotypes. There is evidence that the relationship of PON1 to vascular disease is, in part, due to its antioxidant activity. However, the physical relationship of PON1 with HDL and existence of cholesterol pathway regulatory elements at the PON1 locus suggests a further relationship of PON1 with lipoproteins, which may contribute to its role in vascular disease. We investigated the relationship of PON1 activity and genotype with lipid-related traits in 91 Caucasian men with severe carotid artery disease and 184 without vascular disease who were not on lipid lowering medications. Prior studies of PON1 relationship to lipids have not stratified by disease status. We found that PON1 activity was correlated with HDL traits in controls and with LDL and VLDL related traits in cases. We hypothesize differences in the joint regulation of PON1 and lipoproteins in cases and controls.
Revised on June 22, 2005
Accepted on June 24, 2005
The correlation of paraoxonase (PON1) enzyme activities with plasma lipid and lipoprotein levels differs for subjects with and without vascular disease
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Gluba, T. Pietrucha, M. Banach, G. Piotrowski, and J. Rysz The Role of Polymorphisms Within Paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the Modulation of Cardiovascular Risk: A Pilot Study Angiology, February 1, 2010; 61(2): 157 - 165. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Gaidukov and D. S. Tawfik The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity J. Lipid Res., July 1, 2007; 48(7): 1637 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nus, F. Frances, J. Librelotto, A. Canales, D. Corella, J. M. Sanchez-Montero, and F. J. Sanchez-Muniz Arylesterase Activity and Antioxidant Status Depend on PON1-Q192R and PON1-L55M Polymorphisms in Subjects with Increased Risk of Cardiovascular Disease Consuming Walnut-Enriched Meat J. Nutr., July 1, 2007; 137(7): 1783 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Graner, R. W. James, J. Kahri, M. S. Nieminen, M. Syvanne, and M.-R. Taskinen Association of Paraoxonase-1 Activity and Concentration With Angiographic Severity and Extent of Coronary Artery Disease J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2429 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Blatter Garin, X. Moren, and R. W. James Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I J. Lipid Res., March 1, 2006; 47(3): 515 - 520. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |