J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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A more recent version of this article appeared on July 1, 2005

Papers In Press, published online ahead of print April 16, 2005
J. Lipid Res., doi:10.1194/jlr.M500129-JLR200
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Submitted on April 4, 2005
Revised on April 11, 2005
Accepted on April 12, 2005

Cholesterol-lowering effects of dietary blue lupin seeds (Lupinus angustifolius L.) in intact and ileo-rectal anastomosed growing pigs fed cholesterol-rich diets

José M. Martins, Michel Riottot, Manuel C. Abreu, Ana M. Viegas-Crespo, Maria J. Lança, José A. Almeida, João B. Freire, and Ofélia P. Bento

Department of Zootecnia, Universidade de Évora, Évora 7002-554 Évora

Corresponding Author: jmartins{at}uevora.pt

The present study was undertaken to investigate the effect of cholesterol-enriched casein (CAS) and blue lupin seed (BL) diets on the cholesterol metabolism of intact (INT) and ileo-rectal anastomosed (IRA) pigs. For 3 wk, four groups of 6 pigs were allocated to the treatments (CAS-INT, CAS-IRA, BL-INT, and BL-IRA pigs). Diet-induced hypercholesterolemia was inhibited by the BL diet, through a substantial decrease in plasma LDL-cholesterol. The BL diet also reduced liver esterified and total cholesterol, increased hepatic LDL receptor synthesis and HMG-CoA reductase activity, and stimulated intestinal bile acid reabsorption. The neutral sterol output was higher in BL- than in CAS-fed pigs. The bile acid output was lower in IRA than in INT pigs. Surgery also prevented steroid microbial transformation but it did not influence plasma cholesterol levels. These results suggest that the hypocholesterolemic effect of the blue lupin diet, when compared with the CAS diet, is due to impaired intestinal cholesterol absorption, probably involving increased bile acid reabsorption and higher contents in dietary phytosterols, both factors reducing micellar solubilization of cholesterol. Furthermore, the contribution of the large intestine to the cholesterol metabolism is, according to our data, very weak.


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 Poult. Sci.Home page
A. Viveros, C. Centeno, I. Arija, and A. Brenes
Cholesterol-Lowering Effects of Dietary Lupin (Lupinus albus var Multolupa) in Chicken Diets
Poult. Sci., December 1, 2007; 86(12): 2631 - 2638.
[Abstract] [Full Text] [PDF]


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