J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on October 1, 2005

Papers In Press, published online ahead of print August 1, 2005
J. Lipid Res., doi:10.1194/jlr.M500178-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow Supplemental Data
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M500178-JLR200v1
46/10/2221    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moschetta, A.
Right arrow Articles by Hofmann, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moschetta, A.
Right arrow Articles by Hofmann, A. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on May 6, 2005
Revised on July 18, 2005
Accepted on July 18, 2005

A phylogenetic survey of biliary lipids in vertebrates

Antonio Moschetta, Fang Xu, Lee R. Hagey, Gerard P. van Berge Henegouwen, Karel J. van Erpecum, Jos F. Brouwers, Jonathan C. Cohen, Molly Bierman, Helen H. Hobbs, Joseph H. Steinbach, and Alan F. Hofmann

Department of Medicine, University of California, San Diego 92093-0813, San Diego, CA 92093-0813

Corresponding Author: HofmannAF{at}cs.com

Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals) and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C27bile alcohol sulfates, and/or N-acyl amidates of C27 and/or C24 bile acids). Phospholipids were generally absent in the bile of cartilaginous fish and reptiles, and were present in low amounts relative to bile salts in bony fish and most birds. In mammals, the phospholipid/bile salt ratio varied widely. The bile from species with low biliary phospholipid/bile salt ratios often contained a high proportion of sphingomyelin, confirmed by HPLC-MS. In species with a high phospholipid/bile salt ratio, the predominant biliary phospholipid was phosphatidylcholine. The phospholipid/bile salt ratio correlated weakly with the calculated weighted hydrophobic index value. Cholesterol was present in the bile of virtually all species with plant sterols uniformly being present in only trace amounts. The cholesterol/bile salt ratio tended to be higher in mammals than in non-mammals, but bile of all species was unsaturated. Thus, most non-mammalian vertebrates have relatively low levels of biliary phospholipid and cholesterol, suggesting that cholesterol is eliminated predominantly as bile salts. Mammals have a higher phospholipid and cholesterol to bile salt ratio, with the dominant phospholipid being phosphatidylcholine.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
E. J. Reschly, N. Ai, S. Ekins, W. J. Welsh, L. R. Hagey, A. F. Hofmann, and M. D. Krasowski
Evolution of the bile salt nuclear receptor FXR in vertebrates
J. Lipid Res., July 1, 2008; 49(7): 1577 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
D. C. Volz, S. W. Kullman, D. L. Howarth, R. C. Hardman, and D. E. Hinton
Protective Response of the Ah Receptor to ANIT-Induced Biliary Epithelial Cell Toxicity in See-Through Medaka
Toxicol. Sci., April 1, 2008; 102(2): 262 - 277.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. Kakiyama, H. Tamegai, T. Iida, K. Mitamura, S. Ikegawa, T. Goto, N. Mano, J. Goto, P. Holz, L. R. Hagey, et al.
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15{alpha}-hydroxylithocholic acid
J. Lipid Res., December 1, 2007; 48(12): 2682 - 2692.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. Kakiyama, T. Iida, T. Goto, N. Mano, J. Goto, T. Nambara, L. R. Hagey, C. D. Schteingart, and A. F. Hofmann
Identification of a novel bile acid in swans, tree ducks, and geese: 3{alpha},7{alpha},15{alpha}-trihydroxy-5{beta}-cholan-24-oic acid
J. Lipid Res., July 1, 2006; 47(7): 1551 - 1558.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.