J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on November 1, 2005

Papers In Press, published online ahead of print August 16, 2005
J. Lipid Res., doi:10.1194/jlr.M500212-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M500212-JLR200v1
46/11/2398    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Vleuten, G. M.
Right arrow Articles by de Graaf, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Vleuten, G. M.
Right arrow Articles by de Graaf, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on May 25, 2005
Revised on July 20, 2005
Accepted on August 2, 2005

Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile

Gerly M. van der Vleuten, Lambertus J. H. van Tits, Martin den Heijer, Heidi Lemmers, Anton F. H. Stalenhoef, and Jacqueline de Graaf

Department of General Internal Medicine 541, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB

Corresponding Author: G.vandervleuten{at}aig.umcn.nl

Objectives Familial combined hyperlipidemia (FCH) is characterized by elevated levels of total cholesterol, triglycerides and/or apolipoprotein B. Other features of FCH are obesity and insulin resistance. Adiponectin is a secretory product of the adipose tissue. Low levels of adiponectin are associated with insulin resistance and accelerated atherosclerosis. The aim of this study was to determine whether decreased adiponectin levels are associated with FCH and its phenotypes. Methods and Results The study population comprised 644 subjects, including 158 patients with FCH. Serum adiponectin levels were determined using a commercially available ELISA. For both males and females, the mean adiponectin level (µg/ml) was significantly lower in FCH patients (2.0 (1.8-2.2) and 2.5 (2.3-2.8), respectively) compared to normolipidemic relatives (2.3 (2.2-2.5) and 3.1 (2.8-3.3), respectively), and spouses (2.4 (2.1-2.7) and 3.2 (2.8-3.6), respectively), even after adjusting for waist circumference and insulin resistance. Low adiponectin level in FCH patients was a superior independent predictor of the atherogenic lipid profile, including high triglyceride levels, low HDL-cholesterol levels and the amount of small dense LDL present, compared to both obesity and insulin resistance. Conclusions Low adiponectin levels may contribute to the atherogenic lipid profile in FCH, independent of insulin resistance and of obesity, as measured by waist circumference. This finding implies a role of adipose tissue metabolism in the pathophysiology of FCH.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
M. E. Spurlock and N. K. Gabler
The Development of Porcine Models of Obesity and the Metabolic Syndrome
J. Nutr., February 1, 2008; 138(2): 397 - 402.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.