J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on May 1, 2006

Papers In Press, published online ahead of print February 11, 2006
J. Lipid Res., doi:10.1194/jlr.M500517-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M500517-JLR200v1
47/5/1014    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carlson, C. S.
Right arrow Articles by Jarvik, G. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carlson, C. S.
Right arrow Articles by Jarvik, G. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Submitted on November 29, 2005
Revised on January 17, 2006
Accepted on February 10, 2006

TagSNP and haplotype analyses of the paraoxonase gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and carotid artery disease

Christopher S. Carlson, Patrick J. Heagerty, Thomas S. Hatsukami, Rebecca J. Richter, Jane Ranchalis, Julieann Lewis, Tamara J. Bacus, Laura A. McKinstry, Gerard D. Schellenberg, Mark Rieder, Deborah Nickerson, Clement E. Furlong, Alan Chait, and Gail P. Jarvik

Department of Medicine/Division of Medical Genetics, University of Washington Medical Center, Seattle, WA 98195-7720

Corresponding Author: pair{at}u.washington.edu

Paraoxonase (PON1) activity is consistently predictive of vascular disease, although genotype at four functional PON1 polymorphisms is not. To address this inconsistency we investigated the role of all common PON1 genetic variability, as measured by tagSNPs, in predicting PON1 activity for phenylacetate hydrolysis, low density lipoprotein (LDL) susceptibility to oxidation ex vivo, plasma homocysteine (Hcy) levels and carotid artery disease (CAAD) status. The biological goal was to establish if additional common genetic variation beyond consideration of the four known functional SNPs improves prediction of these phenotypes. PON2 and PON3 tagSNPs were secondarily evaluated. Expanded analysis of an additional 26 tagSNPs found evidence of previously undescribed common PON1 polymorphisms that affect PON1 activity independently of the four known functional SNPs. PON1 activity was not significantly correlated with LDL oxidative susceptibility, but genotypes at the PON1-108 promoter polymorphism and several other PON1 SNPs were. Neither PON1 activity nor PON1 genotype was significantly correlated with plasma Hcy levels. This study revealed previously undetected common functional PON1 polymorphisms that explain 4% of PON1 activity and a high rate of recombination in PON1, but the sum of the common PON1 locus variation does not explain the relationship between PON1 activity and CAAD.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
P. W. Connelly, G. F. Maguire, C. M. Picardo, J. F. Teiber, and D. Draganov
Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma
J. Lipid Res., January 1, 2008; 49(1): 245 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
S. Cronin, M. J Greenway, J. H M Prehn, and O. Hardiman
Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis
J. Neurol. Neurosurg. Psychiatry, September 1, 2007; 78(9): 984 - 986.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.