J. Lipid Res.
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A more recent version of this article appeared on July 1, 2006

Papers In Press, published online ahead of print April 28, 2006
J. Lipid Res., doi:10.1194/jlr.M600149-JLR200
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Submitted on March 30, 2006
Revised on April 27, 2006
Accepted on April 28, 2006

Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha ,7alpha ,15alpha -trihydroxy-5beta -cholan-24-oic acid

Genta Kakiyama, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Lee R. Hagey, Claudio D. Schteingart, and Alan F. Hofmann

Department of Medicine (Gastroenterology), University of California, San Diego, La Jolla, CA 92093-0813

Corresponding Author: ahofmann{at}ucsd.edu

By HPLC, a taurine conjugated bile acid with a retention time different from that of taurocholate was found to be present in the bile of the black necked swan, Cygnus melanocoryphus. The bile acid was isolated and its structure, established by 1H and 13C NMR and mass spectrometry, was that of the taurine N-acyl amidate of 3a,7a,15a-trihydroxy-5ß-cholan-24-oic acid. The compound was shown to have chromatographic and spectroscopic properties that were identical to those of the taurine conjugate of authentic 3a,7a,15a-trihydroxy-5ß-cholan-24-oic acid, previously synthesized by us from ursodeoxycholic acid. By HPLC, the taurine conjugate of 3a,7a,15a-trihydroxy-5ß-cholan-24-oic acid was found to be present in 6 of 6 species in the subfamily Dendrocygninae (tree ducks) and in 10 of 13 species in the subfamily Anserinae (swans and geese), but not in other subfamilies in the Anatidae family. It was also not present in species from the other two families of the order Anseriformes. 3a,7a,15a-Trihydroxy-5ß-cholan-24-oic acid is a new primary bile acid that is present in the biliary bile acids of swans, tree ducks, and geese and may be termed 15a-hydroxy-chenodeoxycholic acid.


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G. Kakiyama, H. Tamegai, T. Iida, K. Mitamura, S. Ikegawa, T. Goto, N. Mano, J. Goto, P. Holz, L. R. Hagey, et al.
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15{alpha}-hydroxylithocholic acid
J. Lipid Res., December 1, 2007; 48(12): 2682 - 2692.
[Abstract] [Full Text] [PDF]


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