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Papers In Press, published online ahead of print July 18, 2006
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Medical Department M (Endocrinology & Diabetes), Aarhus University Hospital, Aarhus Dk-8000
Corresponding Author: nielsen.soren{at}dadlnet.dk
Hypertriglyceridemia is considered a cardiovascular risk factor in diabetic and non-diabetic subjects. In this study we aimed to determine potential regulators of Very-Low-Density-Lipoprotein-Triglycerides (VLDL-TG) production. VLDL-TG kinetics was measured in 13 men and 12 women (Body Mass Index (BMI) (mean (range)): 24.8 (20.2-35.6 kg/m2)). VLDL-TG production was assessed from the plasma decay of a bolus injection of ex-vivo labelled VLDL particles ([1-14C]triolein-VLDL-TG). Similar VLDL-TG production (µmol/min) was found in men and women. VLDL-TG production was not significantly correlated with palmitate flux ([9,10-3H]palmitate) (r=0.09,p=0.67) or palmitate concentration (r=-0.29, p=0.2) but correlated significantly with fasting insulin concentration (r=0.46,P<0.05) and resting energy expenditure (REE) (r=0.45,P<0.05). The latter correlation improved when adjusted for sex. The best multivariate model with VLDL-TG production as the dependent variable and REE, body composition, hormones, and substrate levels as independent variables included fasting insulin (p=0.02) and REE (p=0.02) (r2=0.32, p<0.001). We conclude that VLDL kinetics is similar in men and women and that REE and plasma insulin are significant independent predictors of VLDL-TG production. FFA availability and body fat distribution are unrelated to VLDL production. We suggest that REE plays a greater role in VLDL-TG production than previously anticipated. REE and insulin should be taken into account when VLDL-TG production comparisons between groups are made.
Revised on July 13, 2006
Accepted on July 17, 2006
Energy expenditure, insulin, and VLDL triglyceride production in humans
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