J. Lipid Res. Please sign the JLR Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on September 1, 2006

Papers In Press, published online ahead of print June 20, 2006
J. Lipid Res., doi:10.1194/jlr.M600178-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M600178-JLR200v1
47/9/2071    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lingenhel, A.
Right arrow Articles by Kronenberg, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lingenhel, A.
Right arrow Articles by Kronenberg, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Submitted on April 20, 2006
Revised on June 2, 2006
Accepted on June 19, 2006

Role of the kidney for the metabolism of apolipoprotein A-IV: influence of the type of proteinuria

Arno Lingenhel, Karl Lhotta, Ulrich Neyer, Iris M. Heid, Barbara Rantner, Martina F. Kronenberg, Paul König, Arnold von Eckardstein, Maria Schober, Hans Dieplinger, and Florian Kronenberg

Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck A-6020

Corresponding Author: Florian.Kronenberg{at}i-med.ac.at

Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this anti-atherogenic protein. We therefore investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared to 274 controls (mean 21.9±9.6 vs. 14.4±4.0mg/dl, p<0.001)). Decreasing creatinine clearance showed a strong association with increasing apoA-IV levels. However, serum albumin levels significantly modulated apoA-IV levels in patients with low creatinine clearance resulting in lower levels of apoA-IV in patients with low compared to those with high albumin levels (21.4±8.6 vs. 29.2±8.4mg/dl; p=0.0007). Furthermore, we investigated urinary apoA-IV levels in additional 66 patients with a wide variety of proteinuria and 30 controls. Especially patients with a tubular type of proteinuria had significantly higher amounts of apoA-IV in urine than those with pure glomerular type of proteinuria and controls (median 45, 14 and 0.6 ng/mg creatinine, respectively). We confirmed these results in affected members of a family with Dent’s disease who are characterized by an inherited protein reabsorption defect of the proximal tubular system. In summary, our data demonstrate that the increase of apoA-IV caused by renal impairment is significantly modulated by low levels of serum albumin as a measure for the severity of the nephrotic syndrome. From the investigation of apoA-IV in urine as well as earlier immunohistochemical studies we conclude that apoA-IV is filtered through the normal glomerulus and is subsequently mainly reabsorbed by proximal tubular cells.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
B. C.H. Kwan, F. Kronenberg, S. Beddhu, and A. K. Cheung
Lipoprotein Metabolism and Lipid Management in Chronic Kidney Disease
J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1246 - 1261.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.