Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on September 1, 2006

Papers In Press, published online ahead of print June 12, 2006
J. Lipid Res., doi:10.1194/jlr.M600233-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M600233-JLR200v1
47/9/2064    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vaessen, S. F.C.
Right arrow Articles by Khaw, K.-T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaessen, S. F.C.
Right arrow Articles by Khaw, K.-T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on May 31, 2006
Accepted on June 11, 2006

Apolipoprotein av, triglycerides and risk of future coronary artery disease in apparently healthy men and women; the prospective epic-norfolk population study

Stefan F.C. Vaessen, Frank G. Schaap, Jan Albert Kuivenhoven, Albert K. Groen, Barbara A. Hutten, S. Matthijs Boekholdt, Hiroaki Hattori, Manjinder S. Sandhu, Sheila A. Bingham, Robert Luben, Jutta A. Palmen, Nicholas J. Wareham, Steve E. Humphries, John J. P. Kastelein, Phillipa J. Talmud, and Kay-Tee Khaw

Dept. Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ

Corresponding Author: s.f.vaessen{at}amc.uva.nl

In mouse models apolipoprotein (apo) AV exhibits triglyceride-lowering effects. We investigated the apoAV: triglyceride relationship and the association of apoAV with coronary artery disease (CAD) risk by determining serum apoAV levels and genotypes in a nested case (n=1034): control (n=2031) study. In both univariate and multivariate analysis, apoAV levels showed no association with future CAD (p=0.4 and p=0.5, respectively). Unexpectedly there was a significant positive correlation between serum apoAV and TG, in men and women (r=0.36 and 0.28, respectively, p<0.001 each), but a negative correlation between apoAV and LPL mass (r=-0.14 and -0.12, for men and women respectively, p<0.001 each). The frequency of the c.56C>G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoAV and TG levels. For –1131T>C, the minor allele was significantly associated with lower apoAV yet higher TG levels, and was overrepresented in cases (p=0.047). The association of –1131T>C with CAD risk was, however, independent of apoAV levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoAV levels with TG levels, negative correlation with LPL levels and lack of association with CAD risk highlights the need for further human studies to clarify the role of apoAV.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
S. F. C. Vaessen, G. M. Dallinga-Thie, C. J. D. Ross, L. J. Splint, L. W. Castellani, P. C. N. Rensen, M. R. Hayden, F. G. Schaap, and J. A. Kuivenhoven
Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels
J. Lipid Res., May 1, 2009; 50(5): 880 - 884.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
T. M. Forte, X. Shu, and R. O. Ryan
The ins (cell) and outs (plasma) of apolipoprotein A-V
J. Lipid Res., April 1, 2009; 50(Supplement): S150 - S155.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Sierra-Johnson, R. M. Fisher, A. Romero-Corral, V. K. Somers, F. Lopez-Jimenez, J. Ohrvik, G. Walldius, M.-L. Hellenius, and A. Hamsten
Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population
Eur. Heart J., March 2, 2009; 30(6): 710 - 717.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Nilsson, S. Christensen, M. K. Raarup, R. O. Ryan, M. S. Nielsen, and G. Olivecrona
Endocytosis of Apolipoprotein A-V by Members of the Low Density Lipoprotein Receptor and the Vps10p Domain Receptor Families
J. Biol. Chem., September 19, 2008; 283(38): 25920 - 25927.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
L. Nelbach, X. Shu, R. J. Konrad, R. O. Ryan, and T. M. Forte
Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice
J. Lipid Res., March 1, 2008; 49(3): 572 - 580.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
H. Grallert, E.-M. Sedlmeier, C. Huth, M. Kolz, I. M. Heid, C. Meisinger, C. Herder, K. Strassburger, A. Gehringer, M. Haak, et al.
APOA5 variants and metabolic syndrome in Caucasians
J. Lipid Res., December 1, 2007; 48(12): 2614 - 2621.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Sierra-Johnson, A. Romero-Corral, V. K. Somers, F. Lopez-Jimenez, G. Walldius, A. Hamsten, M.-L. Hellenius, and R. M. Fisher
ApoB/apoA-I ratio: an independent predictor of insulin resistance in US non-diabetic subjects
Eur. Heart J., November 1, 2007; 28(21): 2637 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. A. Hegele and R. L. Pollex
Apolipoprotein A-V Genetic Variation and Plasma Lipoprotein Response to Fibrates
Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1224 - 1227.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C.-Q. Lai, D. K. Arnett, D. Corella, R. J. Straka, M. Y. Tsai, J. M. Peacock, X. Adiconis, L. D. Parnell, J. E. Hixson, M. A. Province, et al.
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study
Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1417 - 1425.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement