| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print August 24, 2006
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Biochemistry and Molecular Pharmacology, West Virginia University, Health Sciences Center, Morgantown, WV 26506-9142
Corresponding Author: fbhillgartner{at}hsc.wvu.edu
In avians and mammals, agonists of the liver X receptor (LXR) increase the expression of enzymes comprising the fatty acid synthesis pathway. Here, we investigate the mechanism by which the synthetic LXR agonist, T0-901317, increases the transcription of the acetyl-CoA carboxylase-
Revised on August 9, 2006
Accepted on August 23, 2006
The mechanism mediating the activation of acetyl-CoA carboxylase-
gene transcription by the liver X receptor agonist T0-901317
(ACC) gene in chick embryo hepatocyte cultures. Transfection analyses demonstrate that activation of ACC transcription by T0-901317 is mediated by a cis-acting regulatory unit (-101 to -71 bp) that is comprised of a LXR response element (LXRE) and a sterol regulatory element (SRE). The SRE enhances the ability of the LXRE to activate ACC transcription in the presence of T0-901317. Treating hepatocytes with T0-901317 increases the concentration of mature sterol regulatory element-binding protein-1 (SREBP-1) in the nucleus and the acetylation of histone H3 and histone H4 at the ACC LXR response unit. These results indicate that T0-901317 increases hepatic ACC transcription by directly activating LXR•retinoid X receptor (RXR) heterodimers and by increasing the activity of an accessory transcription factor (SREBP-1) that enhances ligand induced-LXR•RXR activity.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. A. Major, K. Ryan, A. J. Bennett, A. L. Lock, D. E. Bauman, and A. M. Salter Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster J. Lipid Res., July 1, 2008; 49(7): 1456 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tanaka, L. M. Aleksunes, R. L. Yeager, M. A. Gyamfi, N. Esterly, G. L. Guo, and C. D. Klaassen NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 655 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. You, Q. Cao, X. Liang, J. M. Ajmo, and G. C. Ness Mammalian Sirtuin 1 Is Involved in the Protective Action of Dietary Saturated Fat against Alcoholic Fatty Liver in Mice J. Nutr., March 1, 2008; 138(3): 497 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Talukdar, S. Bhatnagar, S. Dridi, and F. B. Hillgartner Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-{alpha} gene transcription by the liver X receptor agonist T0-901317 J. Lipid Res., December 1, 2007; 48(12): 2647 - 2663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Cha and J. J. Repa The Liver X Receptor (LXR) and Hepatic Lipogenesis: THE CARBOHYDRATE-RESPONSE ELEMENT-BINDING PROTEIN IS A TARGET GENE OF LXR J. Biol. Chem., January 5, 2007; 282(1): 743 - 751. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
