Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on November 1, 2006

Papers In Press, published online ahead of print August 28, 2006
J. Lipid Res., doi:10.1194/jlr.M600277-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M600277-JLR200v1
47/11/2400    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, W.-J.
Right arrow Articles by Cohen, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, W.-J.
Right arrow Articles by Cohen, D. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on June 23, 2006
Revised on August 7, 2006
Accepted on August 28, 2006

Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E deficient mice

Wen-Jun Wang, Juan M. Baez, Rie Maurer, Hayes M. Dansky, and David E. Cohen

Medicine Dept., Gastroenterology Division, Brigham and Women's Hospital, Boston, Massachusetts 02115

Corresponding Author: dcohen{at}partners.org

Phosphatidylcholine transfer protein (PC-TP) is a cytosolic phospholipid binding protein and a member of the steroidogenic acute regulatory-related transfer (START) domain superfamily. Its tissue distribution includes liver and macrophages. PC-TP regulates hepatic lipid metabolism, and its absence in cholesterol-loaded macrophages is associated with reduced ATP-binding cassette transporter A1-mediated lipid efflux and increased susceptibility to apoptosis induced by unesterified cholesterol. To explore a role for PC-TP in atherosclerosis, we prepared Pctp-/-/Apoe-/- mice and littermate Apoe-/- controls. At 16 w, atherosclerosis was increased in chow fed male, but not female Pctp-/-/Apoe-/- mice. This effect was associated with increases in plasma lipid concentrations. By contrast, no differences in atherosclerosis were observed between male or female Pctp-/-/Apoe-/- mice and Apoe-/- controls fed a Western-type diet for 16 w. At 24 w, atherosclerosis in chow fed male Pctp-/-/Apoe-/- mice tended to be reduced in proportion to plasma cholesterol. Attenuation of atherosclerosis in female Pctp-/-/Apoe-/- mice fed chow or the Western-type diet for 24 w was not attributable to changes in plasma cholesterol or triglyceride concentrations. These findings suggest that PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
E. F. Scapa, A. Pocai, M. K. Wu, R. Gutierrez-Juarez, L. Glenz, K. Kanno, H. Li, S. Biddinger, L. A. Jelicks, L. Rossetti, et al.
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2
FASEB J, July 1, 2008; 22(7): 2579 - 2590.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement