J. Lipid Res.
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A more recent version of this article appeared on November 1, 2006

Papers In Press, published online ahead of print August 28, 2006
J. Lipid Res., doi:10.1194/jlr.M600277-JLR200
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Submitted on June 23, 2006
Revised on August 7, 2006
Accepted on August 28, 2006

Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E deficient mice

Wen-Jun Wang, Juan M. Baez, Rie Maurer, Hayes M. Dansky, and David E. Cohen

Medicine Dept., Gastroenterology Division, Brigham and Women's Hospital, Boston, Massachusetts 02115

Corresponding Author: dcohen{at}partners.org

Phosphatidylcholine transfer protein (PC-TP) is a cytosolic phospholipid binding protein and a member of the steroidogenic acute regulatory-related transfer (START) domain superfamily. Its tissue distribution includes liver and macrophages. PC-TP regulates hepatic lipid metabolism, and its absence in cholesterol-loaded macrophages is associated with reduced ATP-binding cassette transporter A1-mediated lipid efflux and increased susceptibility to apoptosis induced by unesterified cholesterol. To explore a role for PC-TP in atherosclerosis, we prepared Pctp-/-/Apoe-/- mice and littermate Apoe-/- controls. At 16 w, atherosclerosis was increased in chow fed male, but not female Pctp-/-/Apoe-/- mice. This effect was associated with increases in plasma lipid concentrations. By contrast, no differences in atherosclerosis were observed between male or female Pctp-/-/Apoe-/- mice and Apoe-/- controls fed a Western-type diet for 16 w. At 24 w, atherosclerosis in chow fed male Pctp-/-/Apoe-/- mice tended to be reduced in proportion to plasma cholesterol. Attenuation of atherosclerosis in female Pctp-/-/Apoe-/- mice fed chow or the Western-type diet for 24 w was not attributable to changes in plasma cholesterol or triglyceride concentrations. These findings suggest that PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations.


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