J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on April 1, 2007

Papers In Press, published online ahead of print January 3, 2007
J. Lipid Res., doi:10.1194/jlr.M600400-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M600400-JLR200v1
48/4/848    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ma, K.
Right arrow Articles by Basselin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ma, K.
Right arrow Articles by Basselin, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on September 6, 2006
Accepted on January 3, 2007

Altered brain lipid composition in cyclooxygenase (COX)-2 knockout mouse

Kaizong Ma, Robert Langenbach, Stanley I. Rapoport, and Mireille Basselin

NIA/BPMS, NIH, Bethesda, MD 20892

Corresponding Author: mirvasln{at}mail.nih.gov

Background: Cyclooxygenase (COX)-2 plays an important role in brain arachidonic acid (20:4 n-6) metabolism, and its expression is upregulated in animal models of neuroinflammation and excitotoxicity. Hypothesis: Brain lipid composition will be altered in COX-2 knockout (COX-2-/-) compared with wild-type (COX-2+/+) mice, reflecting the important role of COX-2 in brain lipid metabolism. Methods: Concentrations of different lipids were measured in high-energy microwaved brain from COX-2-/- and COX-2+/+ mice. Results: Compared with the COX-2+/+ mouse brain, the brain of the COX-2-/- mouse had a statistically significant 15% increase in phosphatidylserine (µmol/g brain wet wt), and significant 37%, 27% and 32% reductions in triacylglycerol and cholesterol concentrations, and in the cholesterol to phospholipid ratio, respectively. The normalized concentration (nmol/µmol) of palmitic acid (16:0) was elevated in phosphatidylserine, as was the brain concentration of unesterified arachidic acid (20:0). Conclusions: A lifetime absence of COX-2 produces multiple changes in brain lipid composition. These changes may be related to reported changes in fatty acid kinetics and in resistance to neuroinflammation and excitotoxicity in the COX-2-/- mouse.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
C. T. Chen, D. W. L. Ma, J. H. Kim, H. T. J. Mount, and R. P. Bazinet
The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations
J. Lipid Res., January 1, 2008; 49(1): 147 - 152.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.