J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on March 1, 2007

Papers In Press, published online ahead of print December 15, 2006
J. Lipid Res., doi:10.1194/jlr.M600431-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M600431-JLR200v1
48/3/693    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anuurad, E.
Right arrow Articles by Berglund, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anuurad, E.
Right arrow Articles by Berglund, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on September 29, 2006
Revised on December 13, 2006
Accepted on December 15, 2006

APO E genotype affect allele-specific APO(a) levels for large APO(a) sizes in African Americans: The harlem-basset study

Erdembileg Anuurad, Guijing Lu, Jill Rubin, Thomas A. Pearson, and Lars Berglund

Medicine, University of California Davis, Sacramento, CA 95817

Corresponding Author: lars.berglund{at}ucdmc.ucdavis.edu

Genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher Lp(a) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apo(a) levels across ethnicity. We determined apo(a) sizes, allele-specific apo(a) levels (i.e. levels associated with alleles defined by size) and the apoE gene polymorphism in 231 African Americans and 336 Caucasians. African Americans, but not Caucasians, with apo e2 genotype had lower levels of Lp(a) compared to those with apo e4 (9.6 vs. 11.2 nmol/L, P=0.034, expressed as square root levels). Distribution of apo(a) alleles across apoE genotypes were similar between African Americans and Caucasians. Among African Americans with large size apo(a), the allele-specific apo(a) level was significantly lower among e2-carriers compared to e3- or e4-carriers (5.4 vs. 6.6 and 7.4 nmol/L; P<0.005, expressed as square root levels), respectively. In contrast, there was no significant difference in allele-specific apo(a) levels across apoE genotype among Caucasians. For large apo(a) sizes, apoE genotype contributed to observed African American-Caucasian differences in allele-specific apo(a) levels.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
E. Anuurad, J. Rubin, A. Chiem, R. P. Tracy, T. A. Pearson, and L. Berglund
High Levels of Inflammatory Biomarkers Are Associated with Increased Allele-Specific Apolipoprotein(a) Levels in African-Americans
J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1482 - 1488.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.