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Papers In Press, published online ahead of print February 3, 2007
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Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032
Corresponding Author: hng1{at}columbia.edu
Prior studies have suggested that fatty acids (FA) liberated in the small intestine from ingested 1,3-diacylglycerol (DAG) are inefficiently incorporated into triglyceride (TG) in enterocytes, with less chylomicron TG entering the circulation postprandially. We found less TG, but more monacylglyerol and DAG, with similar total acylglycerol (AG) in newly secreted chylomicrons after oral DAG or TAG. However, clearance of DAG-chylomicrons was more rapid than TAG-chylomicrons; this was associated with more efficient in vitro lipoprotein lipase (LpL)-mediated lipolysis of DAG-derived chylomicrons. Intravenously infused DAG was also cleared faster than TAG in normal mice, via both LpL-mediated lipolysis and apoE-dependent hepatic uptake. Infusions of TAG, but not DAG, raised plasma TG levels. Greater delivery of DAG-derived FA to the liver during infusion of DAG led to greater TG secretion vs TAG.; this allowed maintenance of similar hepatic TG levels after DAG and TAG infusions. Of note, apoB secretion was similar after DAG vs TAG., indicating assembly of larger very low density lipoproteins after DAG.. Conclusion: Reduced plasma TG levels, after oral or intravenous DAG, result from more efficient clearance of DAG by both LpL-lipolysis and apoE-mediated hepatic endocytosis. DAG emulsions may by useful for intravenous nutrition in people with pre-existing hypertriglyceridemia.
Revised on January 29, 2007
Accepted on February 3, 2007
Comparison of blood clearance, tissue uptake, and hepatic apoB secretion in mice giving triacylglycerol and diacylglycerol emulsions either orally or intravenously
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