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A more recent version of this article appeared on August 1, 2007

Papers In Press, published online ahead of print May 11, 2007
J. Lipid Res., doi:10.1194/jlr.M600525-JLR200
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Submitted on December 11, 2006
Revised on May 7, 2007
Accepted on May 10, 2007

Conjugated linoleic acid differently regulates adipogenesis in stromal vascular cells from subcutaneous adipose tissue and skeletal muscle of neonatal pigs

Xuan Zhou, Defa Li, Jingdong Yin, Jianjun Ni, Bing Dong, Jinxiao Zhang, and Min Du

College of Animal Science, China Agricultural University, Beijing 100094

Corresponding Author: yinjd{at}mafic.ac.cn

Conjugated linoleic acid (CLA), a mixture of isomers of linoleic acid, has previously shown to be able to decrease porcine subcutaneous (SC) adipose tissue levels while increasing the count of intramuscular (IM) adipose tissue in vivo. However, the underlying mechanisms through which it acts are poorly understood. The objective of this study was to investigate the different effects of CLA on adipogenesis in cultured SC adipose tissue and IM stromal vascular cells obtained from neonatal pigs. As shown in the present study, trans-10, cis-12 CLA decreased the expression of adipocyte-specific genes, as well as adipose precursor cell numbers and the accumulation of lipid in cultured SC adipose tissue stromal vascular cells. However, the cis-9, trans-11 CLA did not alter adipogenesis in SC cultures. On the other hand, both CLA isomers increased expression of adipocyte-specific genes in IM cultures, together with the increasing accumulation of lipid and oil red O-stained cells. Collectively, these data show CLA decreased SC adipose tissue but increased IM adipose tissue by different regulation of adipocyte-specific genes expression. These results suggest that adipogenesis in IM adipocytes differs from that in SC adipocytes.


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