| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print April 10, 2007
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309
Corresponding Author: sparagna{at}colorado.edu
The mitochondrial phospholipid, cardiolipin, is required for optimal mitochondrial respiration. In the present study, cardiolipin molecular species and cytochrome oxidase activity were studied in interfibrillar and subsarcolemmal cardiac mitochondria from Spontaneously Hypertensive Heart Failure (SHHF) and Sprague Dawley rats throughout their natural lifespan. Fisher Brown Norway (FBN) and young aortic-constricted SHHF rats were also studied to investigate cardiolipin alterations in aging versus pathology. Additionally, cardiolipin was analyzed in human hearts explanted from patients with dilated cardiomyopathy. A loss of tetralinoleoyl cardiolipin (L4CL), the predominant species in the healthy mammalian heart, occurred during the natural or accelerated development of heart failure in SHHF rats and humans. L4CL decreases correlated with reduced cytochrome oxidase activity (no decrease in protein levels) in SHHF cardiac mitochondria, but with no change in citrate synthase (a matrix enzyme) activity. The fraction of cardiac cardiolipin containing L4CL became much lower with age in SHHF than in Sprague Dawley or FBN mitochondria. In summary, a progressive loss of cardiac L4CL, possibly due to decreased remodeling, occurs in response to chronic cardiac overload, but not aging alone in both interfibrillar and subsarcolemmal mitochondria. This may contribute to mitochondrial respiratory dysfunction during the pathogenesis of heart failure.
Revised on April 9, 2007
Accepted on April 10, 2007
Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. G. Rosca, E. J. Vazquez, J. Kerner, W. Parland, M. P. Chandler, W. Stanley, H. N. Sabbah, and C. L. Hoppel Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation Cardiovasc Res, October 1, 2008; 80(1): 30 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chicco, G. C. Sparagna, S. A. McCune, C. A. Johnson, R. C. Murphy, D. A. Bolden, M. L. Rees, R. T. Gardner, and R. L. Moore Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets Hypertension, September 1, 2008; 52(3): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schlame Thematic Review Series: Glycerolipids. Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes J. Lipid Res., August 1, 2008; 49(8): 1607 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Chess and W. C. Stanley Role of diet and fuel overabundance in the development and progression of heart failure Cardiovasc Res, July 15, 2008; 79(2): 269 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Chicco, S. A. McCune, C. A. Emter, G. C. Sparagna, M. L. Rees, D. A. Bolden, K. D. Marshall, R. C. Murphy, and R. L. Moore Low-Intensity Exercise Training Delays Heart Failure and Improves Survival in Female Hypertensive Heart Failure Rats Hypertension, April 1, 2008; 51(4): 1096 - 1102. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
