J. Lipid Res.
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A more recent version of this article appeared on November 1, 2007

Papers In Press, published online ahead of print August 10, 2007
J. Lipid Res., doi:10.1194/jlr.M700138-JLR200
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Submitted on March 21, 2007
Revised on August 7, 2007
Accepted on August 9, 2007

Lipoprotein inflammatory properties and serum amyloid a levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits

Brian J. Van Lenten, Alan C. Wagner, Mohamad Navab, G. M. Anantharamaiah, Susan Hama, Srinivasa T. Reddy, and Alan M. Fogelman

Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679

Corresponding Author: bvanlent{at}mednet.ucla.edu

Rabbits on a 1% cholesterol diet received injections of vehicle with or without D-4F or L-4F. After 1 month the percent of aorta with atherosclerotic lesions was 24 ± 15% (vehicle), 10 ± 6% (D-4F) (p<0.01 versus vehicle), and 13 ± 9% (L-4F) (p<0.05 versus vehicle). Inflammatory indexes for HDL and LDL were determined by measuring monocyte chemotactic activity after adding rabbit lipoproteins to human endothelial cells. HDL-inflammatory index (HII) and LDL-inflammatory index (LII), respectively, were 1.39 ± 0.24; 1.35 ± 0.29 (vehicle), 0.67 ± 0.26; 0.63 ± 0.38 (D-4F) (p<0.001 versus vehicle), and 0.67 ± 0.2; 0.68 ± 0.32 (L-4F) (p<0.01 versus vehicle). Serum amyloid A (SAA) levels were 95 ± 39, 8 ± 22, and 7 ± 19 µg/mL, respectively, for vehicle, D-4F, and L-4F (p <0.001 versus vehicle). There was no correlation between lesion area and total plasma or HDL-cholesterol levels. In contrast, there was a positive correlation with HII, LII, and SAA (p = 0.002, p = 0.0026, p = 0.0079, respectively). HII correlated closely with SAA levels (r =0.6616; r2 =0.4377, p<0.0001). Thus, HII, LII and SAA are better predictors of lesion area than total plasma or HDL-cholesterol levels in cholesterol-fed rabbits.


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