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A more recent version of this article appeared on September 1, 2007

Papers In Press, published online ahead of print June 30, 2007
J. Lipid Res., doi:10.1194/jlr.M700289-JLR200
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Submitted on June 21, 2007
Accepted on June 29, 2007

Cloning and characterization of the hamster and guinea pig nicotinic acid receptors

April Smith Torhan, Boonlert Cheewatrakoolpong, Lia Kwee, and Scott Greenfeder

Cardiovascular and Metabolic Diseases, Schering-Plough Research Institute, Kenilworth, NJ 07033

Corresponding Author: scott.greenfeder{at}spcorp.com

In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors (GPR 109A). The hamster receptor shares approximately 80-90% identity to the nucleotide and amino acid sequences of human, mouse, and rat, receptors. The guinea pig receptor shares 76-80% identity to the nucleotide and amino acid sequences of these other species. [3H]-nicotinic acid binding affinity at guinea pig and hamster receptors is similar to human (Kd = 121 nM, guinea pig; 72 nM hamster; and 74 nM human) as are potencies of nicotinic acid analogs in competition binding studies. Inhibition of forskolin-stimulated cAMP production by nicotinic acid and related analogs is also similar to the activity in the human receptor. Analysis of mRNA tissue distribution for the hamster and guinea pig nicotinic acid receptors shows expression across a number of tissues with higher expression in adipose, lung, skeletal muscle, spleen, testis and ovary.


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