J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on January 1, 2008

Papers In Press, published online ahead of print October 11, 2007
J. Lipid Res., doi:10.1194/jlr.M700386-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M700386-JLR200v1
49/1/147    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, C. T.
Right arrow Articles by Bazinet, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, C. T.
Right arrow Articles by Bazinet, R. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on August 27, 2007
Revised on October 10, 2007
Accepted on October 11, 2007

The low-density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations

Chuck T. Chen, Dawid W. L. Ma, John H. Kim, Howard T. J. Mount, and Richard P. Bazinet

Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2

Corresponding Author: richard.bazinet{at}utoronto.ca

The brain cannot synthesize n-6 or n-3 polyunsaturated fatty acids (PUFA) de novo and requires their transport from the blood. Two models of brain fatty acid uptake have been proposed. One requires the passive diffusion of unesterified fatty acids through endothelial cells of the blood-brain barrier and the other model requires the uptake of lipoproteins via a lipoprotein receptor on the luminal membrane of endothelial cells. This study tested if the low-density lipoprotein receptor (LDLr) is necessary for maintaining brain PUFA concentrations. Because the cortex has a low basal expression of LDLr while the anterior brain stem has a relatively high expression, we analyzed these regions separately. LDLr-/- and wildtype mice consumed an AIN-93G diet ad libitum until 7 weeks of age. After microwaving, the cortex and anterior brain stem (pons and medulla) were isolated for phospholipid fatty acid analyses. There were no differences in phosphatidylserine, phosphatidylinositol, ethanolamine or choline glycerophospholipid esterified PUFA, saturated or monounsaturated fatty acid concentrations in the cortex or brain stem between LDLr-/- and wildtype mice. The findings demonstrate that the LDLr is not necessary for maintaining brain PUFA concentrations and suggest that other mechanisms to transport PUFA into the brain must exist.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
M. Igarashi, K. Ma, L. Chang, J. M. Bell, and S. I. Rapoport
Rat heart cannot synthesize docosahexaenoic acid from circulating {alpha}-linolenic acid because it lacks elongase-2
J. Lipid Res., August 1, 2008; 49(8): 1735 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. T. Green, S. K. Orr, and R. P. Bazinet
The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids
J. Lipid Res., May 1, 2008; 49(5): 939 - 944.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.