J. Lipid Res.
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A more recent version of this article appeared on January 1, 2004

Papers In Press, published online ahead of print November 1, 2003
J. Lipid Res., doi:10.1194/jlr.R300015-JLR200
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Submitted on September 8, 2003
Revised on November 1, 2003
Accepted on October 20, 2003

Nuclear lipids: Key signaling effectors in the nervous system and other tissues

Robert W. Ledeen and Gusheng Wu

Neuroscience Dept., New Jersey Medical School, UMDNJ, Newark, NJ 07103

Corresponding Author: ledeenro{at}umdnj.edu

Long recognized as quantitatively minor components of nuclei, lipids now command growing interest in light of their diverse signaling and modulating properties in that organelle. This occurs in the various compartments of the nucleoplasm as well as the nuclear envelope. Phospholipids are the primary lipid type, including sphingomyelin, phosphoinositides, and other phosphoglycerides. In addition, cholesterol, gangliosides and other sphingolipids are now coming under scrutiny in relation to functional roles. As part of the emerging picture on nuclear signaling there is considerable interest in metabolic enzymes that synthesize and catabolize nuclear lipids. Current studies suggest the main processes occurring in the nucleus are dependent to a large degree on these lipid-initiated events. Nuclei of nervous system cells have been the subject of such investigation, as have nuclei from liver and other extra-neural cells; among the few comparative studies reported to date there has been no significant differences based on tissue or species


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