| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print December 1, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Genetics, UT Southwestern, Dallas, TX 75390-9046
Corresponding Author: Joachim.Herz{at}UTSouthwestern.edu
The low-density lipoprotein (LDL) receptor family comprises several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. One ligand common to all LDL receptor family members is Apolipoprotein E (ApoE), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in Alzheimer’s disease. This review discusses the role of ApoE and its receptors in the central nervous system, and in particular the signaling mechanisms by which two members of the LDL receptor gene family, ApoER2 and VLDLR, control brain development, normal neuronal positioning and neurotransmission in the adult brain.
Revised on November 20, 2003
Accepted on November 24, 2003
Functions of lipoprotein receptors in neurons
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Arias-Moreno, A. Velazquez-Campoy, J. C. Rodriguez, M. Pocovi, and J. Sancho Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome: IMPLICATIONS OF THE STABILITY AND Ca2+ AFFINITY OF THE FIFTH BINDING MODULE OF THE LDL RECEPTOR J. Biol. Chem., August 15, 2008; 283(33): 22670 - 22679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shen, P. Tso, S. C. Woods, D. J. Clegg, K. L. Barber, K. Carey, and M. Liu Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats Diabetes, August 1, 2008; 57(8): 2092 - 2098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Olson, V. P. Winfrey, K. E. Hill, and R. F. Burk Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells J. Biol. Chem., March 14, 2008; 283(11): 6854 - 6860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Willnow, A. Hammes, and S. Eaton Lipoproteins and their receptors in embryonic development: more than cholesterol clearance Development, September 15, 2007; 134(18): 3239 - 3249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Liu, C. Xie, J. A. Richardson, S. D. Turley, and J. M. Dietschy Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease J. Lipid Res., August 1, 2007; 48(8): 1710 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kurumada, A. Onishi, H. Imai, K. Ishii, T. Kobayashi, and S. B. Sato Stage-Specific Association of Apolipoprotein A-I and E in Developing Mouse Retina Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1815 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Contreras-Alcantara, J. A. Godby, and S. E. Delos The Single Ligand-binding Repeat of Tva, a Low Density Lipoprotein Receptor-related Protein, Contains Two Ligand-binding Surfaces J. Biol. Chem., August 11, 2006; 281(32): 22827 - 22838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Hoe, A. Pocivavsek, G. Chakraborty, Z. Fu, S. Vicini, M. D. Ehlers, and G. W. Rebeck Apolipoprotein E Receptor 2 Interactions with the N-Methyl-D-aspartate Receptor J. Biol. Chem., February 10, 2006; 281(6): 3425 - 3431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Van Dooren, D. Muyllaert, P. Borghgraef, A. Cresens, H. Devijver, I. Van der Auwera, S. Wera, I. Dewachter, and F. Van Leuven Neuronal or Glial Expression of Human Apolipoprotein E4 Affects Parenchymal and Vascular Amyloid Pathology Differentially in Different Brain Regions of Double- and Triple-Transgenic Mice Am. J. Pathol., January 1, 2006; 168(1): 245 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Fryer, R. B. DeMattos, L. M. McCormick, M. A. O'Dell, M. L. Spinner, K. R. Bales, S. M. Paul, P. M. Sullivan, M. Parsadanian, G. Bu, et al. The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice J. Biol. Chem., July 8, 2005; 280(27): 25754 - 25759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sinagra, D. Verrier, D. Frankova, K. M. Korwek, J. Blahos, E. J. Weeber, O. J. Manzoni, and P. Chavis Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro J. Neurosci., June 29, 2005; 25(26): 6127 - 6136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Lane and M. R. Farlow Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease J. Lipid Res., May 1, 2005; 46(5): 949 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Cheng, R Huang, I S Lanham, H M Cathcart, M Howard, E H Corder, and S E Poduslo Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease J. Med. Genet., February 1, 2005; 42(2): 129 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. May, A. Rohlmann, H. H. Bock, K. Zurhove, J. D. Marth, E. D. Schomburg, J. L. Noebels, U. Beffert, J. D. Sweatt, E. J. Weeber, et al. Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice Mol. Cell. Biol., October 15, 2004; 24(20): 8872 - 8883. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
